Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been recently diagnosed with a specific type of blood cancer called Ph+ B-cell Acute Lymphoblastic Leukemia (ALL) and have not yet received treatment for it, with a certain protein (CD22) present on at least 20% of your cancer cells.
• You are 18 years of age or older.
• Your bone marrow testing shows at least 20% cancer cells, along with a specific genetic marker confirmed by laboratory testing; or, if a bone marrow biopsy is not possible due to your condition, you have a high enough number of cancer cells in your blood to confirm the diagnosis.
• You are generally able to carry out daily activities, with only mild limitations at most (confirm with trial site).
• Your heart, liver, kidneys, and other organs are working well enough as shown by medical tests.
• It has been at least 2 weeks since any major surgery, radiation, or participation in another clinical trial, and you have recovered from any significant side effects from those treatments.
• You are willing and able to sign a consent form agreeing to take part in the study.
• If you are a woman who could become pregnant, you agree to use effective birth control during the treatment and for at least 8 months after your last dose of the study drug.
• If you are a man with a female partner who could become pregnant, you agree to use effective birth control during treatment and for at least 5 months after your last dose of the study drug.
• You are willing and able to attend scheduled visits, follow the treatment plan, and complete all required tests and procedures.

Who may not be able to join:

• Your leukemia is only found outside of the bone marrow and is not affecting the bone marrow itself.
• You have been diagnosed with a different type of leukemia called Burkitt's or mixed-lineage leukemia.
• Your leukemia has spread to your brain or spinal fluid (central nervous system).
• You have already received treatment for ALL, except for a short course (7 days or fewer) of certain steroids or a specific medication, or a single dose of chemotherapy given directly into the spinal fluid; people taking long-term steroids for other conditions (such as asthma) may still be eligible.
• You currently have or have had a chronic hepatitis B or C infection, or are HIV-positive with a detectable viral load (those with HIV but an undetectable viral load may still be eligible).
• You had major surgery within the last 2 weeks before joining the study.
• You have an unstable or serious uncontrolled medical condition, such as heart or lung problems.
• You currently have another type of cancer, unless it is a minor skin cancer, early-stage cervical cancer, or prostate cancer already fully treated — or you had a previous cancer but have been cancer-free for at least 2 years and are not currently receiving treatment for it.
• You have uncontrolled heart disease.
• Your heart's electrical activity (measured by an ECG) shows a reading above a certain level (confirm with trial site).
• You have a history of chronic liver disease (such as cirrhosis) or suspected alcohol misuse.
• You have a history of a serious liver condition involving blocked blood vessels in the liver (confirm with trial site).
• You currently have a serious active infection (such as blood poisoning) or have had a severe deep tissue infection (such as a bone infection) within the last 4 months.
• You are taking certain medications known to affect heart rhythm in a specific dangerous way (confirm with trial site for specific medications).
• You are pregnant or breastfeeding, or are not willing or able to use effective contraception as required by the study.
• You work at the trial site, are a close relative of someone who does, or are a Pfizer employee directly involved in running this trial.
• You are currently taking part in another clinical trial during the active treatment period of this study.
• You have any other serious medical, mental health, or laboratory condition that the lead doctor believes could put you at greater risk or affect the study results.

Important: Always verify eligibility with the trial site directly before applying.