Peripheral Arterial Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

As a patient participant:

• People who are older than 20 years of age at the time of screening.
• People who have chronic kidney disease with a moderate reduction in kidney function (a specific kidney filtering measure called eGFR must be between 15 and 60), and whose kidney function has been stable for at least 30 days before joining.
• People who have peripheral artery disease (reduced blood flow in the limbs) with symptoms rated at a certain level of severity, confirmed by specific tests such as blood pressure measurements in the ankle and leg, or imaging scans.

As a control group participant (for comparison purposes):

• People who are older than 20 years of age at the time of screening.
• People whose kidney function is in the normal range (eGFR above 60).
• People who do not have peripheral artery disease.

Who may not be able to join:

• People whose kidney function is very severely reduced (eGFR below 15).
• People who are severely malnourished, shown by a very low albumin (protein) level in the blood (below 2.0 g/dL).
• People with severe anaemia or active bleeding in the digestive tract, shown by a very low haemoglobin level (below 8 g/dL).
• People who have a peptic ulcer, swollen veins in the oesophagus (food pipe), a bowel blockage, or who are currently not eating or drinking.
• People who have previously had surgery on their digestive system.
• People who have chronic constipation — defined as fewer than 3 bowel movements per week, straining, hard stools, feeling of incomplete emptying, or being unable to pass stool — unless laxatives are able to produce a bowel movement, in which case this condition may not be an obstacle (confirm with trial site).
• People who have had a major bleeding event requiring a blood transfusion during their current hospital admission.
• People who have been diagnosed with advanced liver cirrhosis (Child classification B or C), either confirmed by biopsy or by a doctor's clinical assessment.
• People who have received a solid organ transplant or a blood/bone marrow transplant.
• People who are producing very little urine (less than 500 mL per day), indicating a type of acute kidney injury.
• People whose kidney problems are caused by a blockage in the urinary system or by polycystic kidney disease (an inherited condition where cysts grow on the kidneys).
• People who have taken antibiotics or probiotic supplements within the 2 weeks before joining the trial, or who would need to take them during the follow-up period.

Important: Always verify eligibility with the trial site directly before applying.