Phase 1 Lymphoma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been confirmed through laboratory testing to have advanced cancer that has stopped responding to standard treatments, or where no standard treatment is available — any number of previous treatments is permitted.
• During the dose-finding stage of the trial, people with solid tumours or lymphoma that can be measured or detected on scans may be eligible.
• During the expansion stage of the trial, people must have at least one tumour site that can be clearly measured on scans, and must be willing to have tissue samples (biopsies) taken before and during treatment — the trial site will assess whether a safe biopsy site exists.
• People whose previous cancer treatments (including radiation, major surgery, or experimental therapies) were stopped at least 14 days before starting the trial (or 28 days for certain chemotherapy drugs), and whose side effects from those treatments have mostly resolved.
• People aged 18 or older.
• People who are well enough to carry out basic daily activities (this is measured on a standard scale called ECOG, scores 0–2).
• People whose blood counts, liver function, and kidney function fall within the ranges required by the trial (confirm specific values with the trial site).
• People who are able to understand the study information and are willing to sign a consent form and follow the study schedule.
• Women who are not able to become pregnant (due to surgery or menopause), or who agree to use effective contraception during the trial and for at least 90 days after treatment ends — the same applies to men.

Who may not be able to join:

• People who have brain tumours (metastases) that are causing symptoms — those with brain metastases that have been treated and are not causing symptoms may still be considered, provided treatment finished more than 28 days before joining and steroids for brain swelling are not being used.
• People who are currently participating in another therapeutic clinical trial.
• People with high blood pressure that remains above 150/100 mmHg even with medication.
• People with an active bacterial, fungal, or viral infection (including hepatitis B or C) that requires treatment through an IV drip or antiviral medication.
• People with a known diagnosis of HIV or AIDS-related illness.
• People who have experienced a heart attack, severe chest pain, heart bypass surgery, significant heart failure, stroke, mini-stroke, or serious blood clot in the lungs within the past 6 months.
• People with other serious medical, psychiatric, or laboratory conditions that the investigating doctor believes would make participation unsafe or affect the reliability of the results.
• People who are pregnant or breastfeeding.

Important: Always verify eligibility with the trial site directly before applying.