Phase 3 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older
• People who have been diagnosed with a type of slow-growing blood cancer called follicular lymphoma (FL), confirmed by a tissue sample, that is classified as Grade 1, 2, or 3a, and tests positive for a marker called CD20
• People whose cancer has stopped responding to a treatment called rituximab
• People who are generally well enough to carry out daily activities, rated on a standard medical scale as 0, 1, or 2 (meaning fully active to capable of light work)
• People who have at least one measurable area of cancer visible on a CT scan, meeting specific size requirements
• People with adequate blood cell and organ function levels
• People with a life expectancy greater than 5 years
• People who are willing and able to give written consent and follow the study requirements

Who may not be able to join:

• People whose cancer has already stopped responding to a drug called lenalidomide
• People whose lymphoma has spread to the brain or spinal cord
• People with a serious brain condition called progressive multifocal leukoencephalopathy (PML)
• People who have received certain antibody-based treatments (other than rituximab) within the 3 months before the study starts
• People who have previously received any cancer vaccine
• People who have had radiation therapy within 42 days before joining the study
• People who have had chemotherapy within 28 days before joining the study
• People with a history of another cancer in the last 3 years, except for certain fully treated skin cancers or a specific low-grade cervical condition
• People who have had severe allergic reactions to antibody-based treatments in the past
• People with a known allergy or sensitivity to the drugs thalidomide or lenalidomide
• People who have been regularly taking steroid medications before the start of the trial, unless the steroids are being used for a reason unrelated to lymphoma and at a low dose (confirm with trial site)
• People with serious heart conditions, such as certain types of heart failure, recent heart attack within the last 6 months, or unstable heart rhythms, or serious lung conditions such as obstructive pulmonary disease or a history of airway spasms
• People who have HIV, hepatitis B, or hepatitis C infection (including specific markers detected on blood tests)
• People who are pregnant or breastfeeding

Important: Always verify eligibility with the trial site directly before applying.