Macular Degeneration Trial, Recruiting NCT04847635 Sponsor: Ospedale San Raffaele Condition: Macular Degeneration
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Macular Degeneration Trial, Recruiting

NCT04847635
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People aged 50 years or older
  • People who have reticular pseudodrusen (a type of deposit in the eye) caused by age-related macular degeneration (AMD)
  • People whose best vision (with glasses or contacts if needed) falls within a certain range — roughly from normal vision down to significantly reduced vision (20/20 to 20/400)
  • People with clear eyes — meaning no cloudiness or other issues blocking the view inside the eye
  • People who are able to give their agreement to participate and attend all required appointments during the study

Who may not be able to join:

  • People who have a condition called Geographic Atrophy (an advanced form of AMD involving permanent damage to the retina)
  • People who have abnormal blood vessel growth in either eye (a condition called choroidal neovascularization)
  • People who have previously received any treatment for AMD, except for antioxidant supplements
  • People with cloudiness of the cornea, cataracts, or bleeding inside the eye that could block the laser doctor's view of the target area
  • People with a specific eye condition where the natural lens has been removed and gel from inside the eye has moved to the front of the eye
  • People who have glaucoma caused by abnormal blood vessel growth
  • People who have glaucoma caused by a structural problem present from birth
  • People with certain structural issues in the drainage angle of the eye (confirm with trial site)
  • People with significant swelling or cloudiness of the cornea that blocks a detailed view of the eye's drainage angle
  • People with glaucoma caused by active inflammation inside the eye
  • People with any other eye condition that could worsen during the study and affect vision assessment
  • People taking any eye or general medication known to be harmful to the lens, retina, or optic nerve
  • People with inflammation inside the eye (uveitis) without a known cause, or caused by an autoimmune condition
  • People who have had eye surgery within 3 months before joining the study
  • People who have previously had laser treatment directed at the central part of the retina (the macula)
  • People who have previously had surgery inside the eye to remove the gel (vitrectomy), glaucoma drainage surgery, corneal transplant, or surgery to repair a detached retina
  • People who have previously had radiation treatment in or around the eye area in either eye
  • People who have taken part in a study using an experimental treatment within 60 days before joining
  • Women who could become pregnant — unless they have been postmenopausal for at least 1 year, had a sterilisation procedure at least 6 weeks ago, or are using highly effective contraception during the study treatment period
  • People who have taken part in a study involving an experimental drug, biological treatment, or medical device within 6 months before the start of the study (note: studies involving only over-the-counter vitamins, supplements, or diet changes are not considered exclusionary)

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 20 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Phone: +390226434004

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Sponsor
Ospedale San Raffaele
Registry
ClinicalTrials.gov
Start date
16 March 2021
Est. completion
1 September 2026

Where this trial is recruiting

🇮🇹 Italy

Primary endpoints

Changes in the retinal sensitivity - 12 months; Anatomical changes using structural optical coherence tomography (OCT); Rate of Progression

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 20 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov