Phase 3 Macular Degeneration Trial, Completed

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing to sign a consent form before taking part in the study
• You are 50 years of age or older at the time of screening
• You have never received any anti-VEGF treatment (a type of eye injection therapy) in either eye or anywhere else in your body
• Your eye has been diagnosed with active abnormal blood vessel growth (called CNV) related to age-related macular degeneration (AMD), affecting the central part of your vision, confirmed by imaging tests
• The abnormal blood vessel area makes up more than half of the total problem area in your eye, as confirmed by imaging
• Your vision in the study eye falls within a specific range on a standardised eye chart test (not too good and not too poor — confirm with trial site)
• You are willing and able to attend all study appointments and likely to complete the full study
• Your eyes are clear enough and your pupils can dilate enough to allow good quality photographs to be taken

Who may not be able to join:

• You have ever received anti-VEGF injections or any other investigational treatment in either eye at any time before the study starts
• You have previously received any approved treatment for wet AMD (other than vitamins or dietary supplements) in the study eye
• The abnormal blood vessel growth in your eye is caused by something other than AMD, such as severe short-sightedness, certain eye infections, or other specific eye conditions
• You have any active or suspected infection or inflammation in or around either eye at the time of screening or at the start of the study
• More than half of the problem area in your study eye is made up of scar tissue or damaged tissue
• There is a large amount of bleeding under the retina in your study eye (confirm exact thresholds with trial site)
• There is a tear or rip in a specific layer of your eye (the retinal pigment epithelium) in the study eye
• You currently have or have recently had bleeding inside the eye (vitreous hemorrhage) within 4 weeks before the study starts
• You have had eye surgery (including cataract surgery) within 90 days before the study starts, or certain other eye surgeries at any point in the past, such as retinal detachment surgery, previous laser treatments, or corneal transplants
• You are allergic or sensitive to any of the study medications or to fluorescein dye used in eye imaging
• You have uncontrolled glaucoma (high pressure in the eye) even while on medication
• The lens is missing from your study eye in a way that does not meet specific exceptions (confirm with trial site)
• You have used steroid medications in or around the study eye within the past 6 months, or steroid eye drops for 30 or more days in a row within the past 90 days
• You have had radiation treatment near your eye in the past
• You have other eye conditions in the study eye that could affect your response to treatment or make results difficult to interpret
• Your other (non-study) eye has very poor vision below a certain level, unless it is caused by a treatable condition like a cataract
• You have a condition called scleromalacia (thinning of the white of the eye) in either eye
• You have previously received anti-VEGF treatment anywhere in your body (systemically)
• You have taken steroid tablets or injections for 30 or more days in a row within the past 90 days (unless on a low, stable long-term dose — confirm with trial site)
• You have uncontrolled high blood pressure at the time of screening
• You have had a stroke or heart attack in the 6 months before the study starts
• You have taken part in another clinical trial involving an experimental drug or device recently (within 30 days or longer, depending on the drug — confirm with trial site)
• You have a current infection or had an active infection within 2 weeks before screening
• You have a serious, uncontrolled medical condition affecting major organs or body systems that your doctor feels puts you at too much risk
• You have a medical history that your doctor believes could make it unsafe for you to take part or complete the study
• You are pregnant, breastfeeding, or able to become pregnant and not using a highly effective form of contraception during the study and for 3 months after finishing the study medication

Important: Always verify eligibility with the trial site directly before applying.