Phase 2 Pulmonary Hypertension Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• The baby was born at 36 weeks of pregnancy or later (not very premature).
• The baby weighs between 2.5 kg and 4 kg at birth.
• The baby is between 6 and 72 hours old at the time of joining the trial.
• The baby has been diagnosed with a specific lung blood pressure condition called PPHN, confirmed by a heart ultrasound scan.
• The baby's oxygen levels are severely low, measured by a specific test (called an oxygenation index) showing a reading above 30 on two separate checks at least 15 minutes apart.
• The baby is currently on a breathing machine (mechanical ventilator).

Who may not be able to join:

• The parent or guardian has not given their permission (informed consent) for the baby to take part.
• The baby's mother received a medicine called magnesium sulfate within 48 hours before giving birth.
• The baby has a heart defect, apart from two common and minor ones that many newborns have (a small opening between heart vessels that often closes naturally).
• The baby has a major birth defect, including problems with the diaphragm or underdeveloped lungs.
• The baby has already needed emergency heart and lung resuscitation.
• The baby has very low blood pressure that has not responded to fluids or medicines to support the heart.
• The baby has reduced or impaired kidney function.
• The baby has already been given medicines to improve blood flow in the lungs.
• The baby has stomach or intestinal problems, including bleeding in the digestive tract.

Important: Always verify eligibility with the trial site directly before applying.