Asthma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are a man, or a woman who is not pregnant or breastfeeding, between 20 and 65 years old.
• You have been officially diagnosed with mild asthma, according to recognised asthma guidelines.
• Your asthma has been stable for at least 1 month, and you are using a low-dose inhaled steroid (with or without a reliever inhaler) on a regular basis.
• A breathing test shows your lungs are working at 80% or more of the expected level for someone your age and size (after not using your reliever inhaler for at least 8 hours).
• A special airway sensitivity test (using a substance called methacholine) shows your airways are reactive at a certain level (confirm with trial site).
• You have not smoked for at least 6 months, and your total smoking history is no more than the equivalent of one pack per day for 5 years.
• You are willing and able to sign a consent form agreeing to take part.
• Apart from asthma, you are generally in good health.
• Your body mass index (BMI — a measure of weight relative to height) is between 17 and 35.
• You are able to use a standard metered-dose inhaler (a pressurised puffer inhaler) correctly.
• You are able to do breathing tests properly and consistently, without the effort of blowing causing your airways to tighten.
• If you or your partner could become pregnant, you agree to use an accepted form of contraception throughout the study (such as sterilisation, hormonal contraception, an IUD, condoms with spermicide, or a diaphragm with spermicide).

Who may not be able to join:

• You have had a respiratory infection (such as pneumonia, viral bronchitis, sinusitis, or allergic rhinitis) in the 6 weeks before screening.
• Your breathing test results are below a certain level — specifically, your lung function is below 60% of what is expected, or the volume measured is less than 1.5 litres.
• You have a history of asthma attacks that happen only at certain times of year due to seasonal allergies (confirm with trial site regarding timing).
• You have a history of other serious lung conditions such as cystic fibrosis, COPD, emphysema, tuberculosis, lung cancer, pulmonary fibrosis, or pulmonary hypertension.
• You have a history of heart disease, blood disorders, kidney problems, nerve or brain conditions, liver disease, psychiatric conditions, or hormonal disorders, including certain heart rhythm or electrical abnormalities.
• You were treated in an emergency room or hospitalised for asthma in the 3 months before screening.
• You are allergic or sensitive to any ingredient in the study inhalers or to methacholine.
• You have needed to take steroid tablets or liquid every day in the 3 months before screening.
• You have an abnormal heart rhythm or abnormal heart electrical readings, or specific measurements from a heart tracing (ECG) that are above certain limits.
• You are currently taking, or may need to take, a type of medication called a beta blocker (used for heart or blood pressure conditions).
• You have a history of a certain type of glaucoma (narrow angle), seizures, an overactive thyroid, uncontrolled diabetes, or a condition where inhalers cause airways to tighten instead of opening.
• You have a history of any cancer.
• You have a history of alcohol or drug misuse.
• You have had surgery on your eyes, brain, chest, or abdomen in the 3 months before screening.
• You have used certain asthma medicines (including cromoglicate, leukotriene blockers, theophylline, or long-acting relievers) in the month before screening.
• You have used certain other asthma treatments, including specific biological medicines or high-dose inhaled steroids, in the 6 months before screening (confirm with trial site for full list).
• You are known to be HIV-positive.
• You have taken part in another clinical trial in the month before screening.
• You are pregnant or breastfeeding.

Important: Always verify eligibility with the trial site directly before applying.