Phase 2 Myeloma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are generally able to carry out basic daily activities, even if you need some help at times (this is measured on a standard scale called ECOG, scores 0–2).
• You have been officially diagnosed with multiple myeloma, confirmed by a protein marker found in your blood and/or urine.
• Your myeloma shows measurable levels of disease activity through specific blood or urine tests (confirm exact thresholds with trial site).
• Your myeloma has come back or continued to grow after previous treatment, or has stopped responding to your most recent treatment.
• Depending on which part of the trial you may join, you may need to have had at least 1, or at least 3, previous treatments — including certain types of drugs such as a proteasome inhibitor, an IMiD, and/or an anti-CD38 antibody drug (confirm which group applies to you with the trial site).
• A specific genetic change in your myeloma cells, called a t(11;14) translocation, must be confirmed through a specialist lab test done on a fresh bone marrow sample taken at the start of the trial.
• Your blood counts and organ function (including red blood cells, platelets, white blood cells, and liver function) must be at acceptable levels within 7 days before starting treatment.

Who may not be able to join:

• You have a form of myeloma that does not produce detectable protein markers in the blood (called non-secretory myeloma).
• You have a single isolated tumour made of myeloma cells (called solitary plasmacytoma).
• You have an active condition where myeloma cells are circulating in large numbers in your blood (called plasma cell leukemia).
• You have a related blood condition called Waldenström macroglobulinemia.
• You have a condition called amyloidosis, where abnormal proteins build up in organs.
• You have a rare condition called POEMS syndrome, which affects multiple parts of the body.
• You have a long-term breathing condition that requires you to use oxygen continuously.
• You have had a heart attack within the last 6 months, or have certain other significant heart problems such as severe heart failure, uncontrolled irregular heartbeat, or very poor heart pumping function (confirm details with trial site).
• You have uncontrolled high blood pressure at the time of screening.
• You have previously been treated with a drug called sonrotoclax or other drugs that work in a similar way (such as venetoclax).
• You are known to have HIV.
• You have an active hepatitis B or hepatitis C infection (though people with certain inactive forms of these infections may still be eligible — confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.