Osteoarthritis Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are 20 years of age or older.
- Your shoulder's physical structure is suitable for receiving a shoulder replacement implant.
- You need a shoulder replacement for one of these reasons: wear-and-tear arthritis or bone tissue death (avascular necrosis), rheumatoid arthritis, correcting a deformity, a broken upper arm bone where other treatments haven't worked, or a complex shoulder problem where other treatments are not suitable.
- You are willing and able to attend the required follow-up appointments during the study.
- You are willing and able to sign the consent form approving your participation.
- For a specific type of shoulder replacement called a "reverse" implant: the group of muscles that stabilise your shoulder (rotator cuff) is severely damaged or not working, AND you have severe arthritis and/or a previous shoulder replacement that has failed.
- For the "reverse" implant only: the main muscle that lifts your arm (the deltoid) must still be working.
Who may not be able to join:
- You are unwilling or unable to give consent or attend follow-up appointments.
- You have any condition that the study doctor believes could put you at unnecessary risk or interfere with the study.
- You are currently pregnant or breastfeeding.
- You are considered a vulnerable person, such as a prisoner, someone unable to understand what the study involves, someone with a known alcohol or drug problem, or someone expected not to follow the study requirements.
- You have a neurological condition that makes it difficult or impossible to follow instructions or cooperate with the study team.
- You have any signs of infection in or near your shoulder joint that could spread to the implant.
- Your X-rays show rapid joint breakdown, significant bone loss, or bone being absorbed by your body.
- You have a nerve or muscle disease in the affected arm that would make the surgery inappropriate.
- You have osteoporosis (weak, brittle bones) that your doctor believes would prevent the implant from being properly supported (confirm with trial site).
- You have osteomalacia (softening of the bones).
- You have a metabolic condition that interferes with normal bone growth or healing.
- Your rotator cuff muscles (the group of muscles stabilising the shoulder) are not working — note: this applies to the standard shoulder replacement, not the reverse implant option.
- You have significant damage to the main nerve network running through your upper arm and shoulder (upper brachial plexus).
- The nerve that controls your deltoid muscle (axillary nerve) is paralysed.
- The deltoid muscle or the muscles that rotate your arm outward are not working.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Ryan Boylan, Zimmer Biomet
Phone: 574 268-8610
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Implant Survivorship at 10 years follow-up (Kaplan Meier); Frequency and Incidence of Adverse Events (Safety)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.