Phase 3 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with a specific type of lymphoma called CD20-positive Diffuse Large B-Cell Lymphoma (DLBCL), confirmed by laboratory testing using the 2016 WHO classification system
• People whose lymphoma went into complete remission (no signs of cancer detected) after 4 cycles of a treatment called R-CHOP, as confirmed by a PET-CT scan with a specific score of 1 or 2 on the Deauville scale
• People who have not previously received any treatment for this lymphoma
• People with a low-risk score on a cancer severity scale called the International Prognostic Index (IPI score of 0 or 1)
• People aged 14 to 75 years old
• People whose tumour lesion measured less than 7.5 cm in length
• People with a good general health and activity level, rated 0 or 1 on a standard medical scale called the ECOG scale
• People with a life expectancy of more than 6 months
• People who have given informed written consent to participate

Who may not be able to join:

• People who have previously received any systemic or local cancer treatment, including chemotherapy, for any condition
• People who have previously had an autologous stem cell transplant
• People who have a history of another type of cancer, except for basal cell skin cancer or early-stage cervical cancer
• People who have uncontrolled heart or blood vessel disease, blood clotting disorders, connective tissue diseases, or serious active infections
• People whose lymphoma started in the skin or the central nervous system (brain and spinal cord)
• People whose heart's pumping function (left ventricular ejection fraction) is at or below 50%, as measured by a heart scan
• People with other ongoing, uncontrolled medical conditions that the research team believes would affect their health or participation
• People whose blood test results during the screening period fall outside acceptable ranges — specifically, those with low white blood cell counts, low platelet counts, low haemoglobin (anaemia), or abnormal liver or kidney function — unless those abnormalities are directly caused by the lymphoma (confirm with trial site)
• People with a psychiatric condition or any other situation that may make it difficult for them to follow the trial's requirements
• Women who are pregnant or breastfeeding
• People with certain results on Hepatitis B blood tests may not be eligible unless further testing (HBV-DNA testing) shows the virus is not active; specific rules apply depending on which Hepatitis B markers are detected (confirm with trial site for full details)
• People who are living with HIV
• People who have a TP53 gene mutation in their lymphoma, or people who have not had their lymphoma tested for key genetic mutations (DLBCL hot spot gene screening)

Important: Always verify eligibility with the trial site directly before applying.