COPD Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Healthy control group (40 people): People aged 30–55 with no history of smoking, vaping, or cannabis use (fewer than 100 cigarettes in their lifetime), and whose breathing test results are within the normal range, and who score below 10 on a standard airway symptom questionnaire.
• "GOLD 0" group (roughly one-third of 960 participants): People aged 30–55 who have smoked at least 10 pack-years, and whose breathing test results are within normal range after using a bronchodilator (a medication that opens the airways).
• "PRISm" group (roughly one-third of 960 participants): People aged 30–55 who have smoked at least 10 pack-years, whose airway-to-lung ratio on a breathing test is normal after a bronchodilator, but whose overall airflow is below 80% of what is expected for someone their age and size.
• "GOLD 1–2" group (roughly one-third of 960 participants): People aged 30–55 who have smoked at least 10 pack-years, and whose breathing tests after a bronchodilator show a reduced airway-to-lung ratio but still at least 50% of expected airflow — consistent with early-to-moderate COPD.

Who may not be able to join:

• People with severe asthma, defined as currently being on high-level asthma medication (confirm with trial site for specific medication thresholds), or having had three or more unplanned medical visits for asthma in the past 12 months, or having been hospitalised for asthma in the past 12 months.
• People currently taking part in another clinical trial where the treatment being given is kept secret (blinded).
• People who are pregnant at the time of the first study visit, or who plan to become pregnant during the study — this is due to the risk of radiation exposure from CT scans to an unborn baby.
• People with cognitive difficulties that would prevent them from completing the study tasks.
• People with a BMI (body mass index) above 35 at the start of the study, as higher body weight can affect the quality of CT scan images.
• People with a lung condition other than COPD or asthma — such as interstitial lung disease or pulmonary fibrosis — or another condition that a doctor believes is the main cause of their breathing symptoms.
• People with an illness that is expected to be life-limiting within the next three years.
• People with any metal implants or devices in the upper body that could interfere with CT scan image quality.
• People who have had radiation treatment to the chest, or chest surgery that involved removing lung tissue.
• People with a known HIV/AIDS diagnosis.
• People currently misusing illicit substances (marijuana is excluded from this criterion).
• People with a history of, or who currently use, intravenous (IV) Ritalin.
• People with a history of, or who currently use, heroin.
• People who have used illegal intravenous drugs within the last 10 years, or who have used illegal intravenous drugs on more than 5 occasions at any point in their life.

Important: Always verify eligibility with the trial site directly before applying.