Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

This trial has two groups: a main study group and a control group, each with their own criteria.

Main study group — who may be eligible:

• Adults aged 18 or older
• People newly diagnosed with a specific type of brain lymphoma called Primary Central Nervous System Lymphoma (PCNSL), with medical records, brain scans, spinal fluid samples, and brain biopsy tissue available
• People for whom a brain biopsy and spinal fluid sample (lumbar puncture) are considered safe to perform
• People for whom standard treatments such as intravenous chemotherapy, immunotherapy, or whole-brain radiation are not medically ruled out
• People who have given written consent to take part, with the understanding that withdrawal from the study is always an option without any negative consequences

Control group — who may be eligible:

• Adults aged 18 or older who fall into one of the following categories:
  • Newly diagnosed with a type of lymphoma called DLBCL that carries a high risk of spreading to the brain, or a related high-grade B-cell lymphoma, with relevant medical records, scans, and samples available
  • Newly diagnosed or relapsed with lymphoma that has spread to or involves the central nervous system, with relevant records and samples available
  • Newly diagnosed with a lymphoma confined to the brain or nervous system that is not the DLBCL type
  • People with other brain or nervous system conditions — including brain tumours, degenerative conditions, inflammation, or infection — with relevant records, scans, spinal fluid samples, and where possible, brain biopsy tissue available
• People for whom a brain biopsy and spinal fluid sample (lumbar puncture) are considered safe to perform
• People who have given written consent to take part, with the understanding that withdrawal from the study is always an option without any negative consequences

Who may not be able to join:

Main study group:

• People whose lymphoma involves both the brain/nervous system and other parts of the body at the same time (though they may be considered for the control group)
• People diagnosed with a type of brain lymphoma other than the DLBCL subtype
• People with another serious medical condition that could affect their ability to take part in the trial
• People who are pregnant or breastfeeding; people of childbearing potential who are sexually active would need to use adequate contraception throughout the study
• People who have had another cancer diagnosed or that came back within the last 3 years — though people with certain fully surgically treated early-stage skin or surface cancers may still be considered eligible (confirm with trial site)
• People whose personal, psychological, family, social, or location-related circumstances could make it difficult to follow the study schedule and attend follow-up appointments

Control group:

• People with lymphoma outside the brain or nervous system that is not the DLBCL or high-grade B-cell type, and is not considered high-risk for spreading to the brain
• People with another serious medical condition that could affect their ability to take part in the trial
• People who are pregnant or breastfeeding; people of childbearing potential who are sexually active would need to use adequate contraception throughout the study
• People who have had another cancer diagnosed or that came back within the last 3 years of follow-up — though people with certain fully surgically treated early-stage skin or surface cancers may still be considered eligible (confirm with trial site)
• People whose personal, psychological, family, social, or location-related circumstances could make it difficult to follow the study schedule and attend follow-up appointments

Important: Always verify eligibility with the trial site directly before applying.