Phase 2 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are a woman aged 18 or older
• You are reasonably well and able to carry out daily activities (your doctor will assess this using a standard scale)
• You have been diagnosed with a specific type of ovarian, fallopian tube, or peritoneal cancer (high grade serous or high grade endometrioid), confirmed by a tissue biopsy
• Your most recent chemotherapy treatment included a platinum-based drug (cisplatin or carboplatin)
• You have previously been treated with a type of drug called a PARP inhibitor
• Your cancer responded to your most recent platinum-based chemotherapy
• Your cancer has come back at least 6 months after your last platinum-based chemotherapy, and you need further platinum-based treatment — confirmed by a scan
• Your cancer can be measured on a CT scan taken within 28 days before joining the trial, or you meet certain blood marker criteria if your cancer cannot be measured on a scan (confirm with trial site)
• Your CA125 blood marker level is 100 or above at the screening stage
• You are willing to provide extra blood samples at set points during and after treatment
• You are expected to be able to start treatment within 28 days of being enrolled in the trial
• Your blood tests show that your bone marrow, liver, and kidneys are working well enough
• You are post-menopausal, or if you could become pregnant, you agree to pregnancy testing before treatment and use reliable contraception throughout the trial
• You are willing and able to give your consent and follow the treatment and check-up schedule

Who may not be able to join:

• Your cancer is a type other than high grade serous or high grade endometrioid (for example, non-epithelial ovarian cancer, carcinosarcoma, low-grade, mucinous, or clear-cell carcinoma)
• You need to be treated with a combination of chemotherapy drugs (rather than a single drug)
• You have had a serious allergic reaction to carboplatin in the past
• You are still experiencing significant side effects (grade 2 or higher) from a previous cancer treatment, apart from hair loss or nerve-related side effects
• You have taken part in another clinical trial or received an experimental treatment within the last 28 days
• You have had major surgery within 14 days before your expected treatment start date, or you have not yet fully recovered from surgery
• You have another medical condition, or there are findings from tests or examinations, that could make it unsafe for you to take the trial drug or put you at high risk of complications
• You have a psychological, psychiatric, or other condition that the trial doctor feels could affect your ability to take part or affect the trial results
• You have been treated for another cancer within the last 5 years — with some exceptions such as certain skin cancers, early-stage cervical cancer, breast DCIS, or stage 1 grade 1 womb cancer
• You have active, uncontrolled cancer that has spread to the brain or the lining around the brain causing symptoms (however, stable brain metastases managed with steroids started at least 4 weeks before treatment may be acceptable — confirm with trial site)
• You have pressure on your spinal cord that has not been definitively treated, or your condition has not been stable for at least 28 days
• You are currently pregnant or breastfeeding, or you could become pregnant and are unwilling to use effective contraception from the point of signing consent, throughout treatment, and for at least 6 months after your last dose
• You are unable to attend appointments or follow the treatment and follow-up schedule

Important: Always verify eligibility with the trial site directly before applying.