Early Phase 1 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are 18 years of age or older
• People at U.S. trial sites who can read and understand English or Spanish, or at Canadian sites who can read and understand English or French
• People who have been confirmed or are suspected to have a specific type of cancer affecting the ovaries, fallopian tubes, or the lining of the abdomen (peritoneum), of a moderate to high grade
• People who have not yet received any treatment for this cancer diagnosis
• People who are already planned to receive chemotherapy (a specific type using platinum and taxane drugs, with or without an additional targeted drug) for 3 to 5 cycles before surgery to remove the cancer
• People who have measurable cancer visible on a CT scan taken within the past 12 weeks
• People with a general health and activity level rated as 0, 1, or 2 on a standard medical scale (meaning able to carry out daily activities with minimal to no limitations)
• People who are able to provide a tissue sample (biopsy) for testing, or who have a stored tissue sample from a previous procedure
• People who take blood-thinning medication and whose doctor determines it is safe for them to temporarily stop during the study
• People who are able to swallow pills without difficulty
• People whose blood test results meet specific minimum levels for platelets (a type of blood cell that helps clotting), infection-fighting white blood cells, red blood cell levels (haemoglobin), and kidney function
• People whose liver function blood test results are within an acceptable range
• People who are willing and able to attend all required visits, procedures, and complete questionnaires and a pill diary throughout the study

Who may not be able to join:

• People for whom their doctor determines there is a clear medical reason they should not take aspirin, or should not stop taking aspirin
• People who have had a serious heart or blood vessel event in the past 12 months, such as a heart attack, stroke, heart surgery, significant abnormal heart rhythms, or heart failure
• People with a history of very high blood pressure crises, or whose blood pressure currently measures above 150/90 mmHg when checked by a medical professional within 2 weeks before starting the study
• People with a current or past history of stomach ulcers, severe liver failure, or serious kidney disease that would make taking aspirin unsafe
• People who have had bleeding from the digestive system or urinary tract, or another bleeding or clotting disorder, within the past 6 months
• People with uncontrolled severe inflammation of the oesophagus (food pipe) that has required two or more treatments
• People who have been diagnosed with another cancer in the past 3 years, except for certain common skin cancers
• People with an autoimmune condition that requires ongoing medical treatment
• People who have used steroid medications for 3 weeks or more in the past year, or for any length of time in the past 30 days
• People with a known allergy or sensitivity to aspirin or similar anti-inflammatory medications (NSAIDs)
• People who have had weight-loss (bariatric) surgery
• People who are currently pregnant or planning to become pregnant during the study
• People who have difficulty swallowing medication, or have a digestive condition likely to affect how the study medication is absorbed
• People who have a specific known genetic condition affecting how they process certain medications (G6PD deficiency), or a known issue with a specific liver enzyme involved in drug processing (CYP2C9) (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.