Phase 3 Oesophageal Cancer Trial, Recruiting NCT05187091 Sponsor: All India Institute of Medical Sciences Condition: Oesophageal Cancer
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Phase 3 Oesophageal Cancer Trial, Recruiting

NCT05187091
Recruiting Phase 3

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People aged 18 to 69 years old
  • People receiving radiation therapy for squamous cell cancer of the oropharynx (back of the throat), larynx (voice box), or hypopharynx (lower throat)
  • People with a specific stage of cancer (not spread to distant parts of the body) that has been confirmed by a tissue test, where radiation to both sides of the neck is needed and at least one submandibular gland (a saliva-producing gland under the jaw) can be protected from radiation
  • People whose planned treatment includes radiation therapy combined with chemotherapy (unless chemotherapy is not suitable for them)
  • People with a reasonably good level of physical functioning, as measured by a standard medical score (confirm with trial site)
  • People who are able to attend follow-up appointments over the long term
  • People who are able to complete quality-of-life questionnaires in English or Hindi
  • People who are willing to undergo a FEES procedure (a camera test to assess swallowing)
  • People who have provided written consent to participate

Who may not be able to join:

  • People with early-stage glottic (vocal cord) cancer at a specific low stage with no spread to lymph nodes or distant sites
  • People whose cancer has spread to distant parts of the body
  • People who have previously had radiation therapy to the head or neck area
  • People whose tumour is on one side only and requires radiation to one side of the neck only
  • People who require radiation to both submandibular glands (saliva glands under the jaw)
  • People who had swallowing difficulties before their head and neck cancer diagnosis
  • People who have had major head or neck surgery (not including minor procedures such as biopsies or tonsil removal)
  • People who have a tracheostomy (a breathing tube in the throat)
  • People with another serious illness that, in the doctor's opinion, could interfere with completing treatment, trial assessments, or follow-up
  • People who have had another invasive cancer within the past two years (not including certain types of skin cancer or early-stage cervical cancer)

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 27 July 2026
Phase 3: approximately ~65% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Phone: +917018529339

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 3
Sponsor
All India Institute of Medical Sciences
Registry
ClinicalTrials.gov
Start date
12 July 2021
Est. completion
12 August 2026

Where this trial is recruiting

🇮🇳 India

Primary endpoints

Change in swallowing function post radiotherapy

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov