Phase 2 Pulmonary Hypertension Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- The baby must be a newborn admitted to the Phoenix Children's Hospital NICU (Neonatal Intensive Care Unit)
- The baby must have been diagnosed with congenital diaphragmatic hernia (CDH), which is a condition where there is a hole in the diaphragm (the muscle separating the chest and belly) that allows organs to move into the chest
- The baby must have already had surgery to repair this hole in the diaphragm
- The baby must have had a heart ultrasound (echocardiogram) done 48–72 hours after surgery showing a specific measurement (called LVEI) of 1.4 or higher, which indicates the heart is under strain (confirm with trial site)
- A parent or guardian must give their consent to participate within 24 hours of that heart ultrasound
Who may not be able to join:
- Babies with CDH who did not have surgery to repair the diaphragm
- Babies who did not have a heart ultrasound done 48–72 hours after their surgery
- Babies whose heart ultrasound showed an LVEI measurement below 1.4
- Babies who also have a serious heart defect that requires its own heart surgery as a newborn
- Babies who are known to be allergic to the medication sildenafil
- Babies who are currently being treated with a medication called fluconazole (an antifungal medicine) at the time the study drug would be started
- Cases where a parent or guardian is unable to give consent within 24 hours of the heart ultrasound
- Babies who are currently on a life support machine called ECMO (a machine that helps the heart and lungs work) at the time of the study
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: 801-213-3360
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change in Left Ventricular Eccentricity Index (LVEI) on echocardiogram after 14 days of study treatment compared to baseline echocardiogram as compared to placebo.
Can't join this trial?
Data last synced from ClinicalTrials.gov: 21 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.