Phase 2 Alzheimer's Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with Down syndrome, including mosaic Down syndrome or partial trisomy 21.
• You are willing to sign a consent form (or have a legal representative sign on your behalf) and agree to follow all study requirements for the full length of the study.
• You are between 18 and 55 years old (inclusive).
• You are in generally good health with no diagnosis of dementia.
• Any medications that affect the brain have been at a stable dose for at least 4 weeks (if you recently started a new one, the study team will review your situation individually).
• You have enough vision and hearing to complete thinking and memory tests.
• If you are a female who has not had surgery to prevent pregnancy and have not been through menopause for at least two years, you must have a negative pregnancy test within 24 hours before a brain scan.
• You have a mental age of 4 years or older, based on a specific intelligence test (the KBIT-2).
• English is your first or native language.
• You have a reliable study partner (such as a caregiver, sibling, or parent) who can share information about your health history and symptoms.

Who may not be able to join:

• You have a serious or unstable medical condition that could affect thinking and memory tests, such as unstable heart problems, chronic kidney failure, chronic liver disease, or severe lung disease.
• You are unable to have an MRI scan — for example, if you have a pacemaker, metal fragments near your eyes or spine, or a cochlear implant (note: dental fillings are not a problem).
• You are unable to complete the MRI and PET brain scanning procedures required by the study.
• Your IQ score is below 40 on the KBIT-2 intelligence test.
• You are currently pregnant or breastfeeding.
• You have been diagnosed with cancer in the last 5 years, with some exceptions such as certain minor skin cancers that have been successfully treated (confirm with trial site).
• You have significantly abnormal vitamin B12 or thyroid levels that could interfere with the study, unless follow-up tests show these are not a real concern (confirm with trial site).
• You have other significantly abnormal results from your screening blood tests.
• If spinal fluid collection applies to you: you have a blood clotting or bleeding disorder, or abnormal clotting test results, or you take blood-thinning medication such as warfarin.
• The doctor leading the study at your location decides you are not suitable for another reason.
• You have a clinical diagnosis of dementia.
• You are currently taking part in another clinical trial for an experimental treatment, or another long-term study that uses similar tests or procedures.

Important: Always verify eligibility with the trial site directly before applying.