Phase 1 Oesophageal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be 18 years old or older at the time of signing the consent form
• Doctors expect you to live for more than 12 weeks
• You must be relatively active and able to care for yourself, with only mild limitations on daily activity (confirm with trial site)
• Your cancer must have gotten worse despite standard treatment, or you could not tolerate standard treatment, or no standard treatment is available for your situation
• You must have a stored tumor tissue sample available, or be willing to have a tumor biopsy taken before and during the trial
• Depending on which part of the trial you join, you may need to have one of several specific cancer types, including ovarian, fallopian tube, or peritoneal cancer; endometrial or uterine cancer; stomach, stomach-esophagus junction, or esophageal cancer; triple-negative breast cancer; hormone receptor-positive/HER2-negative breast cancer; or other solid tumors (excluding bone cancers)
• Your cancer must be measurable by CT or MRI scan (applies to certain parts of the trial)

Who may not be able to join:

• You have a serious or uncontrolled heart condition
• You have an abnormal heart tracing (ECG) that doctors consider medically significant
• You currently have an active infection (such as bacterial, fungal, or viral) that requires ongoing medication
• You have cancer that has spread to the brain or spinal cord that has not been treated or has continued to grow
• You have another cancer that is currently active or has required treatment within the last 2 years
• Your recent blood or lab test results fall outside acceptable ranges (confirm with trial site for specific values)
• You have significant uncontrolled medical conditions, including serious liver or digestive system problems
• You have not yet recovered from side effects of previous cancer treatments or complications from a recent surgery
• You have previously been treated with a type of drug called a CDK2 inhibitor
• You have had certain hormone therapies, targeted therapies, antibody treatments, or other specific cancer medications recently before joining (confirm exact timing with trial site)
• You have had major surgery within the 28 days before starting the trial
• You have had radiation therapy within the 28 days before starting the trial
• You are currently taking part in another clinical trial or have taken an experimental drug recently (confirm exact timing with trial site)
• You have an active hepatitis B or hepatitis C infection that needs treatment
• You have a known history of HIV
• You have had a severe allergic reaction to any ingredient in the study treatment

Important: Always verify eligibility with the trial site directly before applying.