Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been newly diagnosed with mantle cell lymphoma (a type of blood cancer) that has not yet been treated, and whose diagnosis has been confirmed by a tissue sample showing a specific marker called CD20+
• People aged 70 or older, or people aged 60–69 if a doctor has determined they are not suitable for high-intensity treatment involving stem cell transplantation
• People whose general health and ability to carry out daily activities meets a certain minimum level, as assessed by a standard medical scoring tool (confirm with trial site)
• People whose heart is functioning well enough, as measured by a specific heart scan showing the heart pumping at least 50% efficiency
• People whose kidneys are functioning well enough, based on blood or urine test results falling within acceptable ranges
• People whose liver is functioning well enough, based on blood test results falling within acceptable ranges
• People whose blood cell counts are at acceptable levels (with some flexibility if low counts are caused by the lymphoma affecting the bone marrow)
• People who are able to give written consent to take part in the trial

Who may not be able to join:

• People whose mantle cell lymphoma is classified as "in-situ" (a very early, localised form)
• People whose lymphoma is classified as Stage 1 (the earliest and most localised stage)
• People who have received treatment for any form of lymphoma (Hodgkin or non-Hodgkin) within the past 5 years
• People who have had another active cancer within the past 3 years, unless it was a limited skin cancer (non-melanoma), papillary thyroid cancer, cervical cancer in situ, breast cancer in situ, or a localised prostate cancer that has been fully treated
• People whose lymphoma has spread to the central nervous system (the brain or spinal cord)
• People who test positive for certain markers of hepatitis B infection, unless a doctor has already started them on appropriate antiviral medication to manage this
• People with a history of hepatitis C infection, unless testing shows the virus is no longer active in their blood
• People with a known history of HIV infection
• People with certain serious or unstable health conditions, including:
  • Severe heart failure
  • A heart attack, unstable chest pain, or serious heart rhythm problems within the past 6 months
  • A significant history of neurological or psychological conditions, including dementia or seizure disorders
  • Severe chronic lung disease causing low oxygen levels
  • A stroke or mini-stroke (TIA) within the past 6 months
  • Wounds, ulcers, or bone fractures that are not healing
  • An active, uncontrolled infection (bacterial, viral, or fungal) requiring ongoing treatment
• People who are currently taking part in another experimental drug trial
• People with a known serious allergic reaction to any of the study drugs: bendamustine, rituximab, cytarabine, or mannitol
• People who have had a major surgery or serious physical injury within 28 days before the trial starts, or a tissue biopsy (open) within 7 days before the trial starts
• Men who have not had a vasectomy and whose partner could become pregnant, unless they agree to use medically recommended contraception during the trial

Important: Always verify eligibility with the trial site directly before applying.