Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 75 years
• People whose general health and ability to carry out daily activities falls within an acceptable range for this trial (rated on a standard scale as 0, 1, or 2) (confirm with trial site)
• People who have been diagnosed with diffuse large B-cell lymphoma (a type of blood cancer) confirmed by a tissue test, have not yet received treatment for it, and are considered at high risk of the cancer spreading to the brain and spinal cord based on specific scoring criteria or the location of the lymphoma in the body (confirm with trial site)
• People who have at least one tumour that can be measured on a scan, meeting minimum size requirements
• People whose blood counts are within an acceptable range, showing the bone marrow is functioning adequately (the trial site may still consider people whose blood counts are affected by the lymphoma itself)
• People whose liver function test results are within an acceptable range
• People whose kidney function is within an acceptable range
• People whose heart pumping function, as measured by a scan or test, is at an acceptable level
• People of reproductive age who agree to use appropriate contraception during the trial; women of reproductive age must have a negative pregnancy blood test within 2 weeks before joining
• People who agree to provide a tissue sample from their diagnosis (either a wax-embedded tissue block from within the past six months, or 20 prepared tissue slides)
• People whose life expectancy is at least 3 months
• People who have signed a consent form agreeing to take part

Who may not be able to join:

• People with a known history of severe allergic reactions to certain types of antibody-based medicines, or who have a medical reason preventing them from receiving the treatment combinations used in this trial
• People who already have signs, symptoms, or test results showing the lymphoma has spread to the brain or spinal cord
• People with certain specific subtypes of diffuse large B-cell lymphoma that are not appropriate for the treatment approach used in this trial (confirm with trial site)
• People with serious heart conditions, including severe heart failure, unstable chest pain, a heart attack within the past 6 months, congestive heart failure, or a specific abnormality on a heart tracing test
• People who had a significant surgical procedure within three weeks before starting treatment
• People currently being treated for another cancer, or diagnosed with another cancer within the past 5 years — though some exceptions may apply, such as certain fully treated skin cancers or cervical changes with no signs of disease remaining
• People with significant problems with blood clotting
• People who have previously received any treatment aimed at their lymphoma, other than a short course of steroid medication (up to 10 days)
• People with a severe active infection
• People with other serious, uncontrolled health conditions that could affect participation, such as uncontrolled diabetes, certain lung conditions, uncontrolled high blood pressure, or other significant conditions
• People with active hepatitis B or hepatitis C infections at certain levels, or with HIV, or other immune deficiency conditions
• People who are pregnant or breastfeeding

Important: Always verify eligibility with the trial site directly before applying.