Phase 3 Ovarian Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with ovarian, fallopian tube, or primary peritoneal cancer that cannot be surgically removed, confirmed by a tissue biopsy from a previous treatment.
• Your cancer is one of these specific types: high-grade serous, endometrioid, or clear-cell ovarian cancer (certain mixed tumors may also qualify — confirm with trial site).
• You are generally able to carry out daily activities with little or no limitation (your doctor rates your physical fitness as 0 or 1 on a standard scale).
• Your doctor expects you to live for at least 6 more months.
• You have already received at least 3 rounds (lines) of cancer treatment, including your first-line treatment.
• Your cancer has either stopped responding to platinum-based chemotherapy during treatment, or came back within 6 months of finishing it.
• You have previously been treated with bevacizumab (or a similar drug).
• You have no medical reason that would prevent you from receiving carboplatin, cisplatin, or bevacizumab.
• Your cancer has gotten worse after your most recent treatment, confirmed by a scan.
• You have at least one measurable area of cancer visible on an abdominal or pelvic scan.
• Scans or a physical exam show that cancer is likely present inside the abdominal cavity (on the lining of the abdomen).
• Your kidneys, liver, blood counts, blood clotting, and immune system are all functioning at an adequate level.

Who may not be able to join:

• Your cancer is of a specific type not covered by this trial, such as mucinous, low-grade serous, squamous cell, small cell, or non-epithelial types (e.g., germ cell or sex-cord tumors).
• You have had a bowel blockage in the last 3 months.
• You currently have an active infection, such as a urinary tract infection, pneumonia, or other serious infection.
• You are currently experiencing active bleeding in your digestive system.
• Cancer has spread to your brain or spinal cord.
• You have an inflammatory bowel disease (such as Crohn's disease or ulcerative colitis).
• You have a known history of HIV infection.
• You have had an active hepatitis B or hepatitis C infection within the last 4 weeks.
• You have had a blood clot in a vein or artery in the past 3 months.
• Certain physical conditions of your abdomen would make it unsafe to place the catheter used in this trial (confirm with trial site).
• You have serious heart problems rated as Class III or IV by your doctor.
• You have had a stroke or mini-stroke (TIA) in the past 6 months.
• Your blood oxygen level is below 90%.
• You have previously received a virus-based gene therapy or treatment using a virus designed to destroy cancer cells.
• You are currently taking antiviral medication.
• You have had another type of cancer that was active in the past 3 years (some early-stage or easily cured skin, bladder, or cervical cancers may still be acceptable — confirm with trial site).
• You have received chemotherapy, radiation, or other cancer treatments within the past 4 weeks.
• You have had surgery within the past 4 weeks, or have not fully healed from a recent surgery.
• You are currently taking immune-suppressing drugs or steroids above a certain dose (confirm with trial site).
• You have rapidly worsening fluid build-up in your abdomen or around your lungs that requires draining more than once every 14 days.
• You have a known allergy to the antibiotic gentamicin.

Important: Always verify eligibility with the trial site directly before applying.