Alzheimer's Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are able to have a lumbar puncture (a procedure to collect fluid from the spine)
• People who are registered with the French Social Security system

Group 1 – Healthy Controls (no memory problems):

• People who have no memory complaints, based on a memory complaint questionnaire
• People with normal cognitive (thinking and memory) test scores for their age and education level
• People who are willing and able to follow the study procedures and sign a consent form after being fully informed

Group 2 – Alzheimer's Disease:

• People who have been diagnosed with probable Alzheimer's disease dementia, according to recognised 2011 medical guidelines
• People who score 16 or above on a standard memory and thinking test (MMSE)
• People who have a study partner (a friend or family member) who can complete some questionnaires and provide a lift home after the lumbar puncture — if neither the participant nor the study partner can drive, travel costs will be covered by the study organiser
• People (and their study partners) who are willing and able to follow the study procedures and sign a consent form; a legal representative may assist with this process if needed

Group 3 – Frontotemporal Dementia:

• People who have been diagnosed with probable frontotemporal dementia, according to recognised 2011 medical guidelines
• People who score 16 or above on a standard memory and thinking test (MMSE)
• People who have a study partner (a friend or family member) who can complete some questionnaires and provide a lift home after the lumbar puncture — if neither the participant nor the study partner can drive, travel costs will be covered by the study organiser
• People (and their study partners) who are willing and able to follow the study procedures and sign a consent form; a legal representative may assist with this process if needed

Who may not be able to join:

• People whose dementia is caused by something other than a brain-degenerating condition, including those with a heavy burden of blood vessel disease in the brain
• People who have a medical reason that prevents them from having a lumbar puncture
• People who have a medical reason that prevents them from having an MRI scan
• People who weigh less than 45 kg
• People who have another brain-degenerating condition, such as Lewy body dementia or Parkinson's disease
• People who have another serious brain or nervous system condition, such as a brain tumour, stroke, epilepsy, or fluid build-up on the brain
• People with a serious metabolic or hormonal disorder (though stable, well-controlled hypothyroidism, type 2 diabetes, or common cholesterol problems may be acceptable — confirm with trial site)
• People who take the medication metformin
• People with a known active hepatitis C (HCV), hepatitis B (HBV), or HIV infection
• People with significant abnormal blood test results, either previously known or found at the screening appointment, based on the doctor's assessment
• People who are pregnant, breastfeeding, or women of childbearing age who are not using effective contraception (a pregnancy test will be carried out)
• People with excessive alcohol intake or drug misuse, based on the doctor's assessment
• People who, in the doctor's opinion, are unlikely to be able to follow the study procedures, or who cannot be contacted in an emergency

Important: Always verify eligibility with the trial site directly before applying.