Phase 1 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with a type of cancer called non-Hodgkin lymphoma, confirmed by a tissue test, where the disease has come back after at least 2 previous treatments, has not responded to chemotherapy, or has returned within 12 months after a stem cell transplant using their own cells.
• People who do not have lymphoma affecting the brain or spinal cord.
• People who are older than 18 years of age.
• People whose general health and ability to carry out daily activities meets a specific medical fitness standard (confirm with trial site).
• People who have at least one measurable area of disease that can be tracked during the trial.
• People who have finished radiation therapy or other cancer treatment at least 2 weeks before the blood collection procedure used in this trial.
• People whose liver function test results fall within acceptable ranges, except in cases of a specific liver condition called Gilbert's syndrome.
• People whose kidney function test results fall within acceptable ranges.
• People whose heart is pumping effectively (above 50% efficiency), with no fluid build-up around the heart, as confirmed by a heart scan.
• People whose lungs are functioning adequately, as measured by blood oxygen levels of 92% or higher while breathing normal air.
• People (or their legal guardians) who are able to understand and willing to sign a written consent form.
• Women who could become pregnant must agree to either abstain from heterosexual intercourse or use a highly effective form of contraception during treatment and for at least 90 days after the treatment infusion.
• Men must agree to either abstain from heterosexual intercourse or use contraception, and must agree not to donate sperm during this period.

Who may not be able to join:

• People who have had a stem cell transplant using their own cells within the past 6 weeks.
• People who have previously had a stem cell transplant using cells from another person (a donor).
• People who currently have an active complication from a donor transplant known as graft-versus-host disease.
• People who have active lymphoma or leukaemia involvement in the brain, spinal cord, or surrounding membranes.
• People who currently have another active cancer, other than certain minor skin cancers or very early-stage cancers that have not spread.
• People who received an experimental treatment less than 28 days before the blood collection procedure for this trial.
• People with a severe form of heart failure classified as the most serious category (New York Heart Association Class IV).
• People who have had a serious heart or blood vessel event — such as a heart attack, stroke, unstable chest pain, or significant irregular heartbeat — within the past 6 months.
• People who currently have an active infection that requires treatment through a drip (intravenous antibiotics or antifungals).
• People who are HIV positive.
• People who are pregnant or breastfeeding.
• People who have signs of a certain type of bone marrow disorder called myelodysplasia, detected on a bone marrow test.
• People who have an active hepatitis B or hepatitis C infection.
• People who have a significant history of neurological conditions affecting the brain, such as epilepsy, uncontrolled seizures, stroke-related complications, severe brain injury, dementia, or Parkinson's disease.
• People who have another illness that is not currently under control.
• People who have another type of cancer that currently requires systemic treatment.
• People who have a history of an autoimmune disease and have needed immunosuppressive medications (other than low-dose steroids) within the past 6 months.

Important: Always verify eligibility with the trial site directly before applying.