Stroke Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older
• People who are presenting between 24 and 72 hours after their stroke began, or after they were last seen to be well
• People who have been diagnosed with an acute ischaemic stroke caused by a blockage in one of the major arteries at the front of the brain (confirmed on brain imaging)
• People whose stroke symptoms score 6 or higher on a standard stroke severity scale at the time of enrolment
• People whose brain scan shows a relatively small area of permanently damaged tissue (less than 50 mL), with a meaningful amount of at-risk but potentially salvageable brain tissue still present (confirmed with a specific type of CT scan called a CT perfusion scan)
• People who are able to provide written consent, or whose legal representative is able to provide consent on their behalf, in line with local requirements

Who may not be able to join:

• People whom the treating doctor considers unlikely to benefit from the trial — for example, those with advanced dementia, significant disability before the stroke, or a high likelihood of early death
• People with serious ongoing illnesses (such as cancer, severe heart failure, or kidney failure) that could affect how outcomes are measured or interfere with follow-up
• People who are pregnant
• People who are unable to have a CT perfusion scan performed
• People with a known allergy to iodine, heparin, or anaesthesia, or who have another clear medical reason why they cannot safely receive an endovascular (catheter-based) procedure
• People who had a seizure at the time of their stroke or before enrolment, if this makes it impossible to accurately measure stroke severity
• People whose blood sugar level is very low (below 50 mg/dL) or very high (above 400 mg/dL) at the time of enrolment
• People with a very low platelet count (below 50,000 per microlitre of blood) at the time of enrolment
• People with a known bleeding disorder, clotting factor deficiency, or those on blood-thinning medication with a clotting level (INR) above 3
• People with very high blood pressure that cannot be brought under control with medication (top number above 220 mmHg or bottom number above 120 mmHg)
• People whose stroke is suspected to be caused by an infected clot, or who are thought to have a bacterial heart valve infection
• People who have already had an endovascular (catheter-based) procedure attempted for this stroke
• People who are unlikely to be available for follow-up assessments after the trial
• People who are currently taking part in another clinical trial that could affect the results of this one
• People with any other condition that the investigator believes would put them at significant risk by participating
• People whose brain scan shows any bleeding in or around the brain (including different types of brain haemorrhage)
• People whose brain scan shows a brain tumour
• People whose brain scan shows significant swelling causing a shift of brain structures to one side
• People with a tear in the main artery from the heart (aortic dissection)
• People who already have a stent (a small mesh tube) placed in the same brain artery affected by the stroke
• People whose blood vessel pathway to the blockage is too difficult or tortuous for the procedure device to safely navigate (confirm with trial site)
• People whose scans show blockages in more than one separate brain artery territory at the same time

Important: Always verify eligibility with the trial site directly before applying.