Phase 2 Crohn's Disease and Colitis Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are between 18 and 74 years old
- You are able to give your own consent to participate in the study
- A doctor has confirmed you have ulcerative colitis (UC) based on standard tests including a camera examination of your bowel and tissue samples
- Your UC is currently active and moderately-to-severely symptomatic, with inflammation reaching at least 15 cm inside your bowel (confirm with trial site for exact scoring details)
- Your doctor has chosen to start you on one of two specific biologic medications: vedolizumab or ustekinumab — and you have either never had a biologic treatment before, OR previous biologic or similar treatments have not worked for you
- If you are a woman who could become pregnant, you are using reliable contraception for at least 4 weeks before and throughout the study
- You are willing and able to follow all study requirements
Who may not be able to join:
- Your UC is severe enough that you need to be treated in hospital
- Your diagnosis is uncertain and not clearly confirmed as ulcerative colitis
- You have had a bowel infection (such as C. difficile or CMV) or been treated for one in the past 4 weeks
- Imaging has shown serious bowel complications such as a dangerously enlarged colon or a hole in the bowel wall
- You have had abdominal surgery in the past 60 days
- You have a very low white blood cell count, or a very high white blood cell count combined with a fever (confirm with trial site for exact values)
- You are currently taking or planning to take another experimental treatment
- You have uncontrolled health conditions such as serious mental health disorders or substance misuse problems
- You have a serious illness that means you are not expected to live for at least 30 more days
- You are pregnant or breastfeeding
- You are unwilling to stop taking non-dietary probiotic supplements
- You have used antibiotics in the past 30 days, or are likely to need antibiotic treatment during the study
- You have had a fecal microbiota transplant (a procedure involving stool from a donor) within the past 3 months
- You have recently used certain medications, including rectal or topical bowel treatments, immunosuppressants, or specific biologic drugs within certain time periods before the study (confirm exact medications and timeframes with trial site)
- The study doctor does not feel that joining this trial is in your best interest
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Proportion of participants with serious adverse events (SAEs) of interest up to week 8 in each group (ie vedolizumab with or without LFMT, ustekinumab with or without LFMT).
Can't join this trial?
Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.