Phase 2 Alzheimer's Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People between the ages of 60 and 85, of any race or ethnicity, and of any sex
• People who score 26 or higher on a standard memory and thinking test called the MMSE (this helps confirm that significant dementia is not present)
• People with a systolic (top number) blood pressure of 130 or higher, with upper limits depending on how many blood pressure medications a person is currently taking (confirm specific limits with trial site)
• People who are willing to be placed into a treatment group randomly and are able to attend follow-up clinic visits over 24 months
• People who are fluent in English or Spanish, and who have adequate vision and hearing to complete thinking and memory tests
• People who have a regular healthcare provider

Who may not be able to join:

• People with a documented history of stroke, significant loss of brain function, or other major brain or blood vessel conditions found through examination or brain scans
• People who have been diagnosed with Alzheimer's disease, another form of dementia, Parkinson's disease, epilepsy/seizure disorder, multiple sclerosis, severe head trauma, or normal pressure hydrocephalus
• People with severe depression (based on a standard questionnaire score), significant mental health conditions such as psychosis or schizophrenia, or a psychiatric disorder that the study doctor believes could interfere with participation; those hospitalised for psychiatric reasons in the past year may be reconsidered after 6 months (confirm with trial site)
• People with unstable heart conditions, such as a heart attack, cardiac bypass surgery within the past 6 months, or congestive heart failure, or other serious medical conditions
• People with a history of atrial fibrillation (an irregular heartbeat) who also have certain additional heart-related symptoms, a resting heart rate below 30 or above 110 beats per minute, or who are taking certain heart rhythm medications (confirm specific medications with trial site)
• People whose systolic blood pressure is 180 mmHg or higher, or whose diastolic (bottom number) blood pressure is 110 mmHg or higher (may be reconsidered after one week)
• People who experience a significant drop in blood pressure when standing up, specifically a systolic reading below 100 mmHg on the third standing measurement (may be reconsidered after two weeks)
• People with a significant history of autoimmune conditions such as lupus, rheumatoid arthritis, or polymyalgia rheumatica
• People with a significant history of alcohol or drug misuse within the past five years
• People with poorly controlled diabetes, defined as a blood sugar marker (HbA1c) above 7.5%, or who require insulin treatment
• People who have been regularly smoking cigarettes within the past year
• People who have a pacemaker or any metal medical device that would prevent a safe MRI scan
• Women who could potentially become pregnant, or who are breastfeeding; only those who are at least two years past menopause or have had a surgical procedure that prevents pregnancy are eligible
• People currently enrolled in another clinical trial of an investigational drug or device, or who have been in one within the past two months
• People with a BMI above 40 (severe obesity), though the study doctor will assess each situation individually
• People with a known allergy to a class of blood pressure medications called angiotensin receptor blockers (ARBs — medications whose names end in "-sartan"), or an allergy to amlodipine
• People with certain abnormal blood test results, such as significantly elevated liver enzymes, poor kidney function, or low red blood cell levels (may be reconsidered after two weeks or longer)
• People with a medical condition that is likely to limit survival to less than three years
• People whom the study doctor judges to be unsuitable for participation for medical, safety, or compliance reasons, including those who plan to move away from the clinic area within two years, those whose family members have significant concerns about participation, those who live in a nursing home, or those who live too far from the clinic for travel to be practical
• Two people who are a couple or live together as partners cannot both participate in the study at the same time

Important: Always verify eligibility with the trial site directly before applying.