Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with Hodgkin Lymphoma (HL) or Acute Myeloid Leukemia (AML) that has come back or gotten worse after previous treatment (previous immunotherapy treatments are allowed)
• If you have HL that has spread beyond the lymph nodes to other parts of the body
• If you have HL and your doctors do not consider you a candidate for high-dose standard chemotherapy
• You are at least 1 year old (there is no upper age limit; the trial includes children, teenagers, and adults treated at the pediatric/adolescent center)
• You are well enough to carry out some daily activities, as measured by standard medical scoring tools (confirm with trial site)
• Your kidneys are working well enough, unless any problems are caused by your illness
• Your liver is working well enough, with certain blood test results within acceptable ranges, unless affected by your illness
• You are able and willing to sign a consent form agreeing to take part in the study
• If you are a woman who could become pregnant, you must have a negative pregnancy test within 72 hours before starting treatment and before each new dose
• Women who could become pregnant must agree to use reliable contraception during the study and for 4 months after the last treatment
• Men must agree to use reliable contraception during the study and for 1 month after the last treatment, not donate sperm during the study or for 30 days after the last treatment, and use a condom during this time; they must also tell their doctor right away if their partner becomes or suspects she may be pregnant

Who may not be able to join:

• You have a known allergy to azacitidine, pembrolizumab, or any of their ingredients
• You have serious, uncontrolled health conditions, such as an active uncontrolled infection, uncontrolled high blood pressure, severe heart failure, or a significant irregular heartbeat
• You are known to have HIV, or currently have active Hepatitis B or C
• You have any other medical, mental health, or personal situation that the study doctor believes could interfere with your safe participation in the trial
• You are currently pregnant or breastfeeding
• You have received a live vaccine (such as certain flu or travel vaccines) within 30 days before starting the study
• You have taken medications that suppress the immune system within 14 days before starting treatment (with some exceptions, such as low-dose steroids, steroid nasal sprays, inhalers, skin creams, or steroid injections into a joint — confirm with trial site)
• You have been diagnosed with certain autoimmune diseases (such as inflammatory bowel disease, celiac disease, or Wegener syndrome) that were active within the past 2 years (note: some milder conditions like asthma, vitiligo, or psoriasis not needing systemic treatment may not disqualify you — confirm with trial site)
• You have known active cancer spread to the brain or the fluid surrounding the brain and spinal cord

Important: Always verify eligibility with the trial site directly before applying.