Oesophageal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed through a biopsy with a specific type of oesophageal or stomach junction cancer (invasive adenocarcinoma of the oesophagus or gastroesophageal junction, Siewart type I–II)
• People whose cancer has spread to nearby lymph nodes or grown into the oesophageal wall, but has not spread to other parts of the body, and where surgery is considered a viable option
• People whose tumour measures no more than 8 cm long and 5 cm wide, based on imaging and/or camera examination of the oesophagus
• People who are reasonably well and able to carry out daily activities, as measured by a standard health scale (ECOG score of 2 or lower)
• People who are able to start radiation treatment within 30 days of signing the consent form
• People aged 18 to 80 years old
• People whose blood counts, kidney, liver, and lung function fall within acceptable ranges, specifically: haemoglobin above 100 g/L, platelet count above 100×10⁹/L, neutrophil count above 1.5×10⁹/L, bilirubin no more than 1.5 times the upper normal limit, creatinine no more than 120 µmol/L, and lung function (FEV1) of at least 1.5 litres
• People who are using adequate contraception if there is any possibility of becoming pregnant
• People who have given written, informed consent to participate

Who may not be able to join:

• People with a history of another cancer, unless it was a non-melanoma skin cancer, a fully treated cervical carcinoma in situ, or a cancer that was successfully cured more than 5 years ago
• People who have previously received chemotherapy or radiotherapy
• People with serious heart conditions, including severe heart failure (New York Heart Association Class III or IV), active chest pain (angina), a heart attack within the past 6 months, a significant irregular heart rhythm requiring medication, or a history of second- or third-degree heart block
• People who already have nerve damage affecting movement or sensation beyond a mild level (above WHO grade 1)
• People with an active infection or another serious medical condition that would make it difficult to safely receive the planned treatment
• People with dementia or a condition that affects their ability to understand and agree to participate in the trial
• People who have lost more than 20% of their body weight in the 3 months before screening
• People who have an oesophageal stent in place
• People who are pregnant or breastfeeding; women of childbearing potential must have a negative blood pregnancy test within 7 days of starting treatment; all people who could potentially cause or become pregnant must use two forms of contraception from the time of signing the consent form until 120 days after completing or stopping the study treatment
• People for whom any part of the treatment is not medically safe, including those with absolute contraindications to radiotherapy or a connective tissue disease
• People who are unable to complete surveys written in English without the help of an interpreter

Important: Always verify eligibility with the trial site directly before applying.