Phase 1 Lymphoma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have signed an informed consent form (or had a legal representative sign on their behalf)
• People aged 18 or older who are well enough to carry out basic daily activities (confirmed by a doctor using a standard health scale)
• People with a confirmed diagnosis of a type of B-cell non-Hodgkin lymphoma (B-NHL), including certain subtypes, who have already received a specified number of prior treatments
• People whose lymphoma cells have a specific protein marker called BAFF-R on their surface
• People with a tumor measuring at least 1.5 cm on a CT or PET scan, or with detectable disease in the blood, bone marrow, digestive tract, skin, or spleen
• People who have previously received CAR T-cell therapy, provided it was at least 3 months before a cell collection procedure and certain levels of those prior CAR T-cells are no longer detected in the blood
• People whose blood counts meet minimum levels — including white blood cells, platelets, and red blood cell-related measures — with some flexibility if lymphoma is present in the bone marrow
• People whose liver function test results are within acceptable ranges
• People whose kidneys are functioning at an adequate level
• People whose heart is pumping well enough and whose heart rhythm and oxygen levels meet specified thresholds
• People who test negative for HIV, and who either test negative for hepatitis B and C, or have an undetectable viral load if previously exposed
• Females of childbearing potential who have a negative pregnancy test and agree to use effective contraception or abstain from sex for at least 3 months after treatment ends

Who may not be able to join:

• People who have previously received a bone marrow or stem cell transplant from another person (allogeneic transplant)
• People who received their own stem cells back in a transplant (autologous transplant) fewer than 6 months before the cell collection procedure
• People currently taking steroid medications or other long-term immune-suppressing drugs
• People whose lymphoma has spread to the heart
• People who need immediate treatment due to serious complications caused by their cancer, such as a blocked bowel
• People with an active autoimmune disease that requires immune-suppressing medication
• People with a primary immune deficiency condition
• People with significant heart problems, including severe heart failure (NYHA Class III or IV), certain irregular heart rhythms, a heart attack within the past 6 months, a stroke within the past 6 months, or a serious blood clot within the past 6 months
• People with certain neurological conditions, including a history of optic neuritis, inflammatory diseases of the brain or nervous system, or a seizure disorder
• People with a history of another cancer, unless it was fully removed or treated with the intent to cure, or has been in remission for at least 3 years
• People with an uncontrolled infection or lymphoma that has spread to the brain or spinal cord (active CNS lymphoma)
• Females who are pregnant or breastfeeding
• People the trial doctors determine may not be safe to participate, or who may not be able to follow the study procedures

Important: Always verify eligibility with the trial site directly before applying.