Phase 3 Glaucoma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with early to moderate open-angle glaucoma (including normal tension glaucoma or pseudoexfoliation glaucoma) in at least one eye within the last 12 months
• People whose eye examination shows an open drainage angle in the eye (a specific structural finding confirmed by a specialist test called gonioscopy)
• Adults aged 18 years or older
• People with vision of at least 6/12 (reasonable functional vision) in at least one eye that also meets the trial's visual field requirements
• People whose visual field test results show no worse than -12dB loss in either eye (a measure of how much side/peripheral vision has been affected)
• Women who could become pregnant must have a negative pregnancy test at the screening and baseline visits before being enrolled
• People who are able to understand and agree to take part in the trial (provide informed consent)
• People who are able and willing to attend all required trial visits and follow the trial procedures for the full duration of the trial

Who may not be able to join:

• People who have a type of glaucoma called pigment dispersion glaucoma
• People who are pregnant, planning to become pregnant during the trial, or currently breastfeeding
• Women who could become pregnant, or male participants whose partner could become pregnant, who are not willing to use highly effective contraception during the trial treatment period and for a specified time after the last trial treatment (confirm with trial site for the exact timeframe)
• People currently taking any of the following medications: isoniazid, pyrazinamide, carbamazepine, phenobarbital, or primidone
• People with a current liver disease, or whose blood tests at the screening visit show elevated liver enzyme levels above a certain threshold
• People whose kidney function tests at the screening visit show significant kidney impairment (an eGFR below 30mL/min/1.73m²)
• People with certain eye or health conditions in both eyes that could affect visual field test results, including:
  • Diabetic retinopathy or other retinal diseases causing vision field loss
  • A cataract serious enough that surgery is likely to be needed within the next 2 years
  • Dementia or other non-glaucoma neurological conditions causing vision field loss
  • Eyelid or surrounding eye structure conditions causing vision field loss (such as blepharochalasis)
• People who have been diagnosed with cancer in the last 5 years, with the exception of certain types of non-melanoma skin cancer
• People with any other health condition that the trial investigator considers would make participation unsuitable
• People who are currently enrolled in another interventional clinical trial, or who have previously taken part in a clinical trial for glaucoma
• People who are currently using and unwilling to stop taking over-the-counter vitamin B3/nicotinamide supplements (including skin products such as ointments or emulsions containing these), Ginkgo Biloba supplements, or Coenzyme Q10 supplements for the duration of the trial

Important: Always verify eligibility with the trial site directly before applying.