Osteoarthritis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older.
• People who have had ongoing front-of-knee pain for more than 12 months that is moderate to severe (a pain score above 4 out of 10 on most or all days, either all the time or when moving).
• People whose knee pain has not been adequately relieved — or who could not tolerate — at least 12 months of conventional treatments, which must have included all three of the following: active physiotherapy, pain medications, and steroid injections into the knee joint.
• People with knee osteoarthritis (OA): imaging taken within the past 12 months must confirm a mild, moderate, or severe grade of OA in the affected knee, as assessed by an independent specialist radiologist.
• People with ongoing pain after a total knee replacement surgery (also called Total Knee Arthroplasty): an orthopaedic review must have ruled out surgical or structural causes for the continued pain.
• People who are willing and able to sign a consent form before any study assessments begin.

Who may not be able to join:

• People with an active local or widespread infection, including infection in the bloodstream.
• People whose knee pain is caused by inflammatory arthritis or another inflammatory condition affecting the whole body.
• People who have had any injection into the affected knee (such as steroids, hyaluronic acid, or platelet-rich plasma) in the three months before the procedure.
• People who are pregnant, breastfeeding, or planning to become pregnant before the study treatment is given.
• People who experience widespread chronic pain across their body (not just the knee).
• People with an unstable psychological or psychiatric condition.
• People with a known allergy to any of the substances used during the procedure, including lidocaine, propofol, or chlorhexidine.
• People with poorly controlled blood clotting problems, defined as taking a higher-than-prescribed dose of blood-thinning medication.
• People with poorly controlled immune suppression.
• People who have participated in another clinical trial within the 30 days before signing the consent form.
• People who currently have a nerve stimulator device implanted in their body.
• People who currently have shooting or radiating pain travelling down the leg on the same side as the affected knee.
• People who have previously had a radiofrequency treatment (standard or cooled) on the affected knee.
• People who have moderate to severe chronic pain in both knees (pain above 4 out of 10 on most or all days for more than 12 months in both knees) that has not responded to at least 12 months of conventional treatments including physiotherapy, pain medications, and steroid injections.
• People who already have a confirmed date scheduled for a total knee replacement surgery.
• People who are unwilling or unable to complete the study questionnaires.

Important: Always verify eligibility with the trial site directly before applying.