Oesophageal Cancer Trial, Recruiting NCT05412758 Sponsor: Imperial College London Condition: Oesophageal Cancer
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Oesophageal Cancer Trial, Recruiting

NCT05412758
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

AROMA 1 part of the trial:

  • People aged 18 to 90 years old
  • People in the cancer group: those who have been diagnosed with adenocarcinoma (a type of cancer) of the oesophagus (food pipe) or stomach through a biopsy, and have not yet received any treatment for it
  • People in the control group: those who have a normal or non-cancerous condition of the upper digestive system, confirmed by an endoscopy done within the last year, or a planned endoscopy coming up

BIORESOURCE part of the trial:

  • People aged 18 to 90 years old
  • People in the cancer group: those who have been diagnosed with adenocarcinoma of the oesophagus or stomach through a biopsy, and have not yet received any treatment for it
  • People in the control group: those who have a normal or non-cancerous condition of the upper digestive system, confirmed by a planned endoscopy

Who may not be able to join:

AROMA 1 part of the trial:

  • People who have a specific type of oesophageal cancer called squamous cell carcinoma
  • People who have previously had surgery to remove part or all of their oesophagus or stomach
  • People who have already received chemotherapy before surgery for oesophageal or stomach cancer
  • People who have had another type of cancer within the past three years
  • People in the control group who have any form of abnormal cell changes (dysplasia) in the oesophagus
  • People in the control group who have previously been diagnosed with Barrett's oesophagus (a condition affecting the lining of the food pipe)
  • People who currently have an active infection, are taking medications that suppress the immune system, or have taken antibiotics within the last 8 weeks
  • People whose other health conditions would prevent them from providing a breath sample (confirm with trial site)
  • People who are allergic to any ingredient in the nutrient drink used in the trial, including glucose, glycerol, iron sulphate, Maltodextrin (from corn or potato), Xanthan Gum, Potassium Chloride, tyrosine, phenylalanine, or glutamic acid
  • People who are not able to give written consent, or who do not wish to do so
  • People who are pregnant

BIORESOURCE part of the trial:

  • People who have a specific type of oesophageal cancer called squamous cell carcinoma
  • People who have previously had surgery to remove part or all of their oesophagus or stomach
  • People who have already received chemotherapy before surgery for oesophageal or stomach cancer
  • People who have had another type of cancer within the past five years
  • People in the control group who have any form of abnormal cell changes (dysplasia) in the oesophagus
  • People in the control group who have previously been diagnosed with Barrett's oesophagus
  • People who currently have an active infection, are taking medications that suppress the immune system, or have taken antibiotics within the last 8 weeks
  • People whose other health conditions would prevent them from providing a breath sample (confirm with trial site)
  • People who are not able to give written consent, or who do not wish to do so
  • People who are pregnant

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 15 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: George Hanna, PhD, FRCS, Imperial College London

Phone: 02075948847

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Registry
ClinicalTrials.gov
Start date
28 February 2022
Est. completion
1 July 2025

Where this trial is recruiting

🇬🇧 United Kingdom

Primary endpoints

Efficacy of an oral nutrient drink to stimulate the production of volatile organic compounds detected in the breath.

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 15 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov