Alzheimer's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with amnestic mild cognitive impairment (MCI) or mild Alzheimer's disease
• People between the ages of 50 and 90
• People who speak English
• People who are able to give their own informed consent to participate
• People who have normal hearing and vision, or who use aids such as glasses or hearing devices that bring these to a normal level

Who may not be able to join:

• People who are currently enrolled in another clinical trial
• People who are currently using immunotherapy medications for cognition, specifically Aduhelm, Leqembi, or Kisunla
• People who have been diagnosed with moderate or severe Alzheimer's disease
• People who are not able to give their own informed consent
• People who weigh more than 275 pounds
• People who are pregnant, who think they may be pregnant, or who are trying to become pregnant
• People who experience claustrophobia (fear of enclosed spaces)
• People who have had difficulties during a previous MRI scan
• People with certain dental hardware that cannot be removed, including a top permanent retainer, five or more non-removable gold teeth, metal braces, top spacers, or a palate expander (a bottom-only permanent retainer is acceptable)
• People who have any of the following implanted devices: a cardiac pacemaker, aneurysm clips, cochlear implants, a defibrillator, implanted electrodes or wires, any magnetically activated device, a spinal cord stimulator, infusion or insulin pumps, an implanted drug delivery device, or a deep brain stimulation device
• People with hairpieces, hair extensions, or piercings that cannot be removed
• People with facial tattoos or permanent makeup
• People with metal implants that are not safe for MRI, or where there is not enough information available to confirm MRI safety (confirm with trial site)
• People who have had a metallic object such as a bullet, BB, or shrapnel enter their body and do not have a doctor's confirmation that it was fully removed
• People who have been diagnosed with any of the following neurological conditions: Parkinson's disease, ALS (Lou Gehrig's disease), multiple sclerosis, or cerebral palsy
• People who have been diagnosed with cystic fibrosis or sickle cell disease
• People who have been diagnosed with bipolar disorder or psychosis
• People with a psychiatric illness that has not been stable and well-managed for at least the past two months
• People with severe lung, liver, heart, or kidney disease, such as heart failure or liver failure
• People who have been diagnosed with a thyroid disorder or who have had their thyroid medication dose changed in the last three months
• People who have received chemotherapy or radiation treatment to the head or neck, or who have stage 4 (metastatic) cancer
• People with an autoimmune disorder or a viral infection such as HIV, COVID-19, or hepatitis C that is currently affecting their memory or thinking
• People with a history of substance abuse within the past year
• People who have had a stroke (a mini-stroke where symptoms lasted less than one week is not automatically disqualifying — confirm with trial site)
• People with a history of two or more seizures, or a diagnosis of epilepsy, unless the seizures occurred before age 5 and were associated with a fever
• People with a history of a brain tumor, brain aneurysm, brain hemorrhage, or subdural hematoma
• People who have had a head injury that caused loss of consciousness lasting more than 30 minutes, cognitive problems lasting more than 18 months, or visible brain abnormalities on a CT or MRI scan
• People with uncontrolled high blood pressure or uncontrolled diabetes
• People who have had a heart attack within the past year

Important: Always verify eligibility with the trial site directly before applying.