Osteoarthritis Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who are willing and able to give their consent to take part in the study
- People aged 45 years or older
- People who have knee osteoarthritis graded 1 to 3 on an X-ray (using a standard medical grading scale)
- People who have had knee pain for at least 3 months that has not improved with non-surgical treatments such as physiotherapy, steroid injections, weight loss programs, or platelet-rich plasma (PRP) injections
- People who are able to lie flat for at least 6 hours (the trial site will ask about sleeping position and anything that prevents lying flat, such as breathlessness or back pain)
- People whose knee pain scores at least 50 out of 100 on a standard pain scale at the start of the trial
Who may not be able to join:
- People who have rheumatoid arthritis or arthritis caused by infection
- People whose knee osteoarthritis is graded as severe (grade 4) on an X-ray
- People with reduced kidney function below a certain level, as measured by a blood test or medical records
- People who have a condition that affects blood clotting, or who take blood-thinning medication (such as warfarin) that cannot easily be stopped — for example, people with certain heart valve conditions; specific blood test results outside safe ranges would also exclude participation
- People who need supplemental oxygen when walking
- People with a life expectancy of less than one year
- People who have significant difficulty communicating due to language barriers
- People for whom an MRI scan is not safe or suitable
- People with known allergies to certain substances used in the procedure, including barium sulfate, 3-aminopropyltrialkoxysilane, polyphosphazene, or contrast dye used in imaging (confirm with trial site)
- People with a history of poor blood circulation in the legs (peripheral arterial disease) that causes pain when walking or at rest
- People who are pregnant or who have a positive pregnancy test, due to exposure to radiation during the procedure
- People with any other significant illness or condition that the recruiting doctor believes could put them at risk or affect the results of the study
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Mark W Little, MD, Royal Berkshire NHS Foundation Trust, Reading, UK
Phone: 2068903102
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Determine if embolisation of abnormal neovasculature arising from branches of the genicular arteries reduces pain in patients with knee OA compared to Sham treatment
Can't join this trial?
Data last synced from ClinicalTrials.gov: 21 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.