Schizophrenia Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are male or female, of any race or ethnicity
- You are 18 years of age or older, whether currently in hospital or receiving care as an outpatient
- You have been diagnosed with schizophrenia or schizoaffective disorder (according to DSM-V standards)
- You are able to understand and agree to take part in the research on your own
- You have been taking the same dose of antipsychotic medication (taken by mouth) and any other regular medications for at least 2 months, with no expected changes during the study
- You are already enrolled in the related parent study (REB# 103-2018)
Who may not be able to join:
- You are unwilling or unable to give informed consent, as assessed by a specific competency test (the MacArthur Test of Competence)
- You have an unstable or serious physical health condition, or a neurological condition, including a history of seizures
- You are currently having thoughts of suicide or harming others
- You have a significant level of disorganised thinking, as measured by a standard psychiatric rating scale (confirm with trial site)
- You have had a serious problem with substance use (other than caffeine, nicotine, or cannabis) within the past month
- You tested positive for drugs (other than cannabis) on a urine test at your screening visit
- You have metal implants or a pacemaker that would prevent you from having an MRI scan, or you have another reason you cannot have an MRI (such as claustrophobia)
- You are pregnant
- You scored below a certain level on a reading and learning ability test (the Wide Range Achievement Test-III) (confirm with trial site)
- You have received long-acting injectable antipsychotic medication in the last 6 months
- You have already been exposed to too much radiation this year to safely have a PET scan (confirm with trial site)
- You are taking certain medications, such as levetiracetam, that could interfere with how the PET scan works
- You have a blood clotting disorder or are taking blood-thinning medication
- You have had so many PET scans in the past that taking part would cause you to exceed the recommended lifetime limit of 8 scans
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Philip Gerretsen, MD, PhD, Centre for Addiction and Mental Health
Phone: 416-535-8501
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Synaptic density changes
Can't join this trial?
Data last synced from ClinicalTrials.gov: 23 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.