Phase 1 Macular Degeneration Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 50 and 75 years old
• You have been diagnosed with late-stage dry age-related macular degeneration (AMD), with one or more areas of damage larger than a certain size in the central part of your eye (confirm with trial site)
• You have been diagnosed with wet AMD but have not responded well to standard treatments
• The vision in your target eye falls within a specific range — not too strong and not too weak (confirm with trial site for exact measurements)
• You are willing to give your informed consent, participate as a volunteer, and attend all required follow-up appointments

Who may not be able to join:

• You only have one functioning eye
• Your macular damage is caused by a condition other than AMD
• You have other eye conditions such as retinitis pigmentosa, diabetic eye disease, or other diseases affecting the retina or blood vessels in the eye, besides AMD
• You have a history of cataracts affecting central vision, glaucoma, uveitis, retinal detachment, optic nerve problems, or similar eye conditions
• You have had eye surgery in the past, other than cataract surgery
• You have had serious health conditions in the past 12 months, such as heart failure, liver disease, kidney problems, or serious lung disease
• You have a serious infectious disease such as HIV, hepatitis B or C, syphilis, or tuberculosis
• Your blood clotting or other laboratory test results are abnormal
• You are female and are currently pregnant, breastfeeding, or planning to become pregnant during the study
• You are male and are unwilling to use barrier contraception and spermicide during the study
• You have or have had a malignant (cancerous) tumor
• You have any condition that affects your immune system
• You are allergic to tacrolimus or similar medications (macrolides)
• You have taken steroids, immunosuppressive drugs, or certain psychiatric medications in the past 3 months
• You are currently taking blood-thinning medications, or your blood's clotting ability has not returned to normal within 10 days of stopping anti-clotting medication
• You have a history of alcohol addiction or use of prohibited drugs
• You are currently taking part in another clinical trial or receiving another experimental treatment
• You are unlikely to be able to complete the study, or you are unwilling to give your consent
• You have a mental health condition, cognitive difficulties, or other circumstances that could affect your safety or the study results (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.