Phase 2 Prostate Cancer Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are a male adult who speaks English
- Your doctor believes you are expected to live for more than 10 years
- You have had an MRI-guided biopsy of a visible area on your prostate MRI before joining the trial (including additional biopsy samples taken in a standard pattern)
- You have been diagnosed with a specific type and stage of prostate cancer (Grade Group 2 or 3, limited to one area, and confined within the prostate — with any lower-grade cancer nearby being very small, 6mm or less)
- Your prostate cancer has been confirmed as adenocarcinoma (a specific cancer type) through a biopsy
- Your cancer has not spread beyond the prostate, and there is no clear sign it has grown into nearby tissues or glands on MRI
- Your biopsy was done through a specific approach and included at least 2 targeted samples plus a standard 12-sample pattern
- Your PSA blood test result is 15 or below, or meets a related measurement if it is higher (confirm with trial site)
- Your doctor can fully see your prostate using ultrasound during the biopsy
- Your doctor believes the affected area of your prostate can be treated with cryotherapy (freezing treatment)
- You are willing and able to read and sign the consent form for this study
- You are willing to follow all study requirements, including the freezing treatment and all follow-up appointments
- You agree to take part in a related laboratory research study
Who may not be able to join:
- Your prostate cancer is classified as a higher grade (Grade Group 4 or 5)
- You have another medical condition that your doctor believes makes surgery or anesthesia too risky for you
- You currently have a urinary tract infection
- You have previously received any treatment for prostate cancer, including radiation, hormone therapy, biological therapy, or chemotherapy
- You have previously had a prostate procedure such as TURP, laser treatment, microwave treatment, water-based treatment, UroLift, or surgical removal of part of the prostate (confirm with trial site for specific procedures)
- You have had previous rectal surgery (other than a minor hemorrhoid procedure) or have a history of rectal disease
- You are unable to have an MRI scan, for example due to claustrophobia, a pacemaker, or certain implants in your body
- You are not willing to take part in the related laboratory research study
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Justin Gregg, MD, jrgregg@mdanderson.org
Phone: 713-792-3250
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Quality-of-life Questionnaires
Can't join this trial?
Data last synced from ClinicalTrials.gov: 23 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.