Phase 3 Alzheimer's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older who are already enrolled in a related study called UNICORN (IRB #842873).
• People who fall into one of seven specific groups: (1) those with no known brain or cognitive conditions and no family history of early-onset brain disease in parents or siblings; (2) those diagnosed with a non-memory-focused form of Alzheimer's disease; (3) those diagnosed with a brain condition likely caused by a protein called tau (such as PSP, CBS, or certain speech and behaviour conditions); (4) those diagnosed with a brain condition likely caused by a protein called TDP-43 (such as ALS-FTD or a language condition called svPPA); (5) those enrolled in UNICORN with a gene change in the MAPT gene linked to tau-related brain disease, whether or not they have symptoms; (6) those enrolled in UNICORN with a gene change in the GRN gene or the C9orf72 gene linked to TDP-43-related brain disease, whether or not they have symptoms; or (7) those diagnosed with memory-focused mild cognitive impairment or Alzheimer's disease.
• People who score within a certain range on a standard depression screening (done within the past 6 months), or who have been assessed by a trained clinician as not clinically depressed.
• People in groups 2 through 7 who have a study partner able to take part as required by the trial, and a legal authorised representative if applicable (confirm with trial site).

Who may not be able to join:

• People with medical or psychiatric conditions that, in the investigator's opinion, could affect their safety or ability to take part in the study.
• People whose UNICORN study records show significant structural brain changes — such as a major stroke or growth on the brain seen on an MRI scan within the past 6 months — that could interfere with the brain scan used in this trial.
• People who are unable to tolerate, or who have a medical reason preventing them from having, the imaging procedures used in this study.
• People who are pregnant or breastfeeding at the time of the first brain scan (a urine pregnancy test will be carried out for women who could become pregnant, at screening and within 24 hours before any scheduled scan).
• People with a significant history of past or ongoing alcohol or substance misuse (this may be assessed at the investigator's discretion).
• People who are currently taking part in another clinical trial for a treatment aimed at changing the course of their brain disease at a biological level.

Important: Always verify eligibility with the trial site directly before applying.