Pulmonary Hypertension Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- Adults aged 18 or older.
- People diagnosed with pulmonary arterial hypertension (PAH) — a condition causing high blood pressure in the lungs — where the cause is unknown (idiopathic), inherited (heritable), linked to connective tissue disease, caused by certain drugs or toxins, or related to a simple heart defect present from birth called an atrial septal defect.
- People whose PAH symptoms fall into World Health Organization (WHO) functional class I, II, or III — meaning symptoms range from none at all up to noticeable limitations during physical activity, but not the most severe level (confirm with trial site).
- People whose PAH medications have been stable for at least three months before joining, with only one minor fluid (diuretic) dose adjustment allowed in that time; minor adjustments to intravenous prostacyclin for managing side effects are also permitted.
- People whose lung function test (measuring how much air the lungs can hold) shows a result above 65% of the expected value, with little to no scarring of lung tissue based on imaging reviews.
Who may not be able to join:
- People who cannot carry out normal day-to-day activity because they use a wheelchair, are confined to bed, rely on a cane or walker, or have activity-limiting chest pain, severe joint problems, or any other condition that significantly limits movement.
- People who are pregnant.
- People whose PAH has a cause other than those listed in the inclusion criteria above.
- People with the most severe level of heart failure, classified as WHO functional class IV.
- People whose fluid (diuretic) medication has needed more than two dose adjustments in the three months before joining.
- People whose main form of physical activity cannot be tracked by a standard activity tracker — for example, swimming, yoga, ice skating, stair climbing machines, or wheel-based activities such as cycling or rollerblading.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Evan Brittain, MD, Vanderbilt Medical Center
Phone: 615-322-3412
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change in Quality of Life as measured by the Short Form Survey (SF-36); Change in Quality of Life as measured by the emPHasis-10
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.