Alzheimer's Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

People with normal aging and no memory problems:

• Adults aged 40 and older who have no signs of cognitive impairment and score at least 22 on a standard memory test (MMSE)
• People who are willing to sign a consent form agreeing to take part

People with subjective cognitive concerns (SCI):

• Adults aged 40 and older who do not have dementia, perform normally on standard cognitive tests, but feel their memory or thinking has gotten worse compared to before, and are concerned about it

People with mild cognitive impairment (MCI):

• Adults aged 40 and older who have been diagnosed with mild cognitive impairment according to recognised 2004 Peterson criteria, score 0.5 on a standard dementia rating scale, and have a gradual and slow onset of memory problems

People with Alzheimer's disease (AD):

• Adults aged 50 and older who have been diagnosed with Alzheimer's disease according to recognised medical criteria, and who are able to attend follow-up appointments (or have a legal guardian who can sign consent on their behalf)

People with vascular cognitive impairment (VCI):

• Adults aged 40 and older diagnosed with small vessel vascular cognitive impairment, where cognitive decline has lasted 3 months or more, and whose brain scans (MRI) show specific patterns of small strokes or white matter changes meeting detailed criteria set out by the trial (confirm with trial site)

Who may not be able to join:

• People who have another condition already known to cause memory or thinking problems, such as Lewy body dementia, frontotemporal dementia, Parkinson's disease dementia, or brain tumours
• People with lasting effects from a serious past brain or nervous system infection, such as autoimmune encephalitis or multiple sclerosis
• People with unstable or poorly controlled epilepsy
• People with significantly abnormal liver or kidney function, including those on dialysis
• People with a hereditary condition known to affect brain function, such as Huntington's disease or Down syndrome
• People with a history of long-term heavy alcohol use (more than 150g per day of high-strength alcohol for over 12 months)
• People with serious lung disease such as chronic obstructive pulmonary disease (COPD) with effects on the brain
• People with serious heart disease, such as heart failure or severe high blood pressure
• People with immune or infection-related conditions affecting the brain, such as untreated HIV or a history of syphilis affecting the nervous system
• People with certain hormone or metabolic conditions that need new or changed treatment, such as thyroid problems or vitamin B12 deficiency
• People with unstable mental health conditions or who have used antipsychotic medications long-term (more than 6 months)
• People who have had an active cancer diagnosis in the past year
• People who cannot have an MRI scan (for example, due to a pacemaker, metal implant, or severe claustrophobia) or cannot participate in PET imaging
• People who have never received any formal education (for some participant groups)
• People with significant hearing or vision difficulties that would prevent cognitive testing
• People with a history of stroke with visible neurological effects and brain scan findings showing significant vascular damage (for SCI and MCI groups)
• People with depression or other conditions that would interfere with cognitive testing
• People who are unwilling to have a blood test
• People who are unwilling to sign a consent form at the start of the study

Important: Always verify eligibility with the trial site directly before applying.