Phase 2 Breast Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing and able to sign a consent form agreeing to take part in the study and allowing their personal health information to be shared.
• Women aged 65 or older who have been newly diagnosed with invasive breast cancer (not a recurrence).
• People whose tumor is classified as a small, early-stage tumor (pathological T1 stage — generally 2 cm or smaller).
• People whose breast cancer tests positive for estrogen and progesterone receptors (meaning the cancer is hormone-sensitive, at 10% or more on lab testing).
• People whose cancer tests negative for a protein called HER2, based on standard laboratory guidelines.
• People whose tumor is classified as Grade 1 or Grade 2 (lower-grade, slower-growing cancers).
• People with no cancer found in nearby lymph nodes, based on clinical assessment or pathology results.
• People with no signs that cancer has grown into nearby blood vessels or lymph vessels in the breast tissue.
• People whose surgery left clear margins of at least 2 mm around the tumor (meaning the surgeon removed enough tissue around the cancer).
• People who have already had breast-conserving surgery (sometimes called a lumpectomy), with or without a lymph node procedure.
• People whom the treating radiation oncologist considers suitable for a targeted radiation treatment called Accelerated Partial Breast Irradiation (APBI).
• People who have had or currently have another type of cancer, as long as that cancer and its treatment are unlikely to interfere with this trial (confirm with trial site).
• People already enrolled in another clinical trial, as long as there is no conflict with this trial's treatments.

Who may not be able to join:

• People who are receiving or planning to receive chemotherapy before or after surgery during the study period.
• People currently taking anti-hormonal medications (such as tamoxifen or aromatase inhibitors), unless those medications are stopped within 30 days of being enrolled in the trial.
• People currently using hormone replacement therapy, unless it is stopped within 30 days of being enrolled in the trial.
• People whose breast cancer appears in more than one area of the same breast.
• People who have had tissue rearrangement procedures inside the area where the tumor was removed.
• People who have been diagnosed with breast cancer in both breasts at the same time.
• People with any signs that the cancer has spread to other parts of the body, based on physical examination or imaging.
• People who have previously had radiation therapy to the breast or chest area.
• People with autoimmune conditions that could increase the risks associated with radiation treatment (confirm with trial site).
• People with serious uncontrolled medical conditions that would make hormone therapy or radiation therapy unsuitable for them.

Important: Always verify eligibility with the trial site directly before applying.