Phase 1 Prostate Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have prostate cancer that has stopped responding to hormone therapy and has come back or not responded to at least one anti-androgen treatment and a chemotherapy regimen containing docetaxel.
• You have a rare cancer called NUT midline carcinoma that has spread or cannot be removed by surgery, and no standard treatments are available.
• You have a blood condition called CMML (a type of bone marrow cancer) that has come back or stopped responding after at least 4 cycles of certain standard treatments (or fewer if you could not tolerate them or your disease got worse).
• You have an advanced form of myelofibrosis (a bone marrow disease, intermediate or high-risk) that did not respond to, or is not suitable for, a type of drug called a JAK inhibitor.
• You have advanced myelofibrosis (intermediate or high-risk) with a low level of abnormal cells in your blood, and a JAK inhibitor stopped working after at least 3 months of treatment.
• You have another type of cancer (solid tumor or blood cancer) that the trial doctors believe may respond to this experimental treatment, after review and approval by the medical team.
• You are generally well enough to carry out daily activities with little or no limitation (confirm with trial site).
• Your doctors expect you to live at least 3 months or more.
• Your disease can be measured or evaluated during the trial.
• Your blood counts meet minimum levels — for example, enough red blood cells, infection-fighting cells, and platelets (specific numbers will be checked by the trial team).
• Your kidneys are working well enough to filter your blood adequately.
• Your liver is working within acceptable limits based on blood tests.
• Your blood clotting is within a normal range (if you are not on long-term blood thinners).
• At least 4 weeks have passed since your last cancer treatment (such as chemotherapy or immunotherapy), or an appropriate amount of time has passed since targeted therapy or radiation, and any side effects from previous treatment have mostly resolved.
• At least 4 weeks have passed since any major surgery.
• If you are able to have children, you agree to use effective birth control during the study and for 4 weeks after your last dose.
• You are able to understand and are willing to sign a consent form agreeing to take part.

Who may not be able to join:

• You have brain or spinal cord cancer that is new or getting worse (however, if brain metastases were previously treated and have been stable for at least 4 weeks, you may still be eligible — confirm with trial site).
• You have a heart condition that causes an abnormally long electrical signal in your heart, shown on an ECG test (confirm with trial site).
• You have serious uncontrolled health problems, such as an active infection requiring IV antibiotics or antifungal medication, severe heart failure, unstable chest pain, irregular heartbeat, or mental health or personal circumstances that would make it difficult to follow the study requirements.
• You are currently pregnant or breastfeeding.
• You have a known history of hepatitis B or hepatitis C that requires antiviral treatment.
• You are living with HIV and your virus is not fully controlled (note: if you are on effective HIV treatment and your viral levels have been undetectable for the past 6 months, you may still be eligible — confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.