Phase 1 Lymphoma Trial, Recruiting NCT05512390 Sponsor: AbbVie Condition: Lymphoma
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Phase 1 Lymphoma Trial, Recruiting

NCT05512390
Recruiting Phase 1 🇦🇺 Australian site

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People with a confirmed diagnosis of a B-cell blood cancer (such as diffuse large B-cell lymphoma, follicular lymphoma, or chronic lymphocytic leukemia), with disease that can be measured on scans and requires treatment.
  • People whose blood and organ function test results fall within the ranges required by the trial.
  • People who have previously been treated with a therapy that targets a protein called CD19, where a tissue sample (biopsy) from the tumour has been collected after that most recent treatment.
  • People whose disease is measurable according to a standard set of guidelines called the 2014 Lugano Classification.

Who may not be able to join:

  • People with known active cancer affecting the brain or spinal cord, or a type of lymphoma that starts in the brain or spinal cord (primary CNS lymphoma).
  • People with a known active infection or other serious uncontrolled medical conditions as specified by the trial (confirm with trial site).
  • People whose general health and ability to carry out daily activities is significantly limited, as measured by a standard scale used by doctors called the ECOG performance status — specifically, those with a score of 2 or higher on that scale (confirm with trial site for details on what this means in practice).

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 16 July 2026
Phase 1: approximately ~10% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: ABBVIE INC., AbbVie

Phone: 844-663-3742

Australian sites

Concord Repatriation General Hospital /ID# 249240, Concord, New South Wales
St Vincent's Hospital Melbourne /ID# 247624, Fitzroy Melbourne, Victoria
One Clinical Research Pty Ltd /ID# 248392, Nedlands, Western Australia

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 1
Sponsor
Registry
ClinicalTrials.gov
Start date
26 April 2023
Est. completion
1 February 2027

Where this trial is recruiting

🇦🇺 Australia 🇨🇦 Canada 🇮🇱 Israel 🇰🇷 South Korea 🇪🇸 Spain 🇺🇸 United States

3 site(s) in Australia. Confirm current status and contact details directly with the trial site.

Primary endpoints

Number of Dose-Limiting Toxicities (DLT); Number of Participants with Adverse Events (AE); Maximum Observed Serum Concentration (Cmax) of ABBV-319; Time to Cmax (Tmax) of ABBV-319; Terminal Phase Elimination Half-Life (t1/2) of ABBV-319; Area Under the Serum Concentration Versus Time Curve (AUC) of ABBV-319; Antidrug Antibody (ADA)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 16 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov