Phase 3 Osteoarthritis Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are at least 30 years old
- You are willing and able to follow the study schedule, attend visits, and understand instructions (spoken and written)
- You are willing to sign a consent form to take part in the study
- Your knee pain scores at least 4 out of 10 on a standard pain scale
- You have ongoing, long-term pain in at least one knee; if both knees are affected, the more painful one will be treated
- Your knee X-ray shows a moderate level of knee arthritis (classified as Grade 2 or 3 on a standard scale called the Kellgren-Lawrence scale)
- Your Body Mass Index (BMI) — a measure of body weight relative to height — is 30 or below
Who may not be able to join:
You have had an injection into the knee (such as steroid, hyaluronic acid, PRP, or a similar treatment) in the past 6 months
Your knee has a significant alignment problem, such as being noticeably bow-legged or knock-kneed (confirm with trial site)
You have another knee problem causing pain or swelling, such as a torn ligament, torn meniscus, or cartilage damage
You have an active infection in the knee being studied
You have been diagnosed with certain types of arthritis or joint conditions, including rheumatoid arthritis, gout, psoriatic arthritis, or several other related conditions (confirm with trial site for the full list)
You have been diagnosed with leukemia, another blood cancer, cancer that has spread to other parts of the body, or you are currently receiving or planning chemotherapy
You have poor blood or fluid circulation in the leg being studied
You have a known allergy to local anaesthetic medications
You have a medical condition that affects blood clotting, such as haemophilia
You have had knee surgery (arthroscopy) in the past 6 months
You have used opioid painkillers daily for the past 3 months, taken anti-inflammatory medications (like ibuprofen) within 1 week of the procedure, or are unable to stop blood-thinning medications
You have used steroid tablets or similar medications for a long-term condition within the past 3 months
You have a condition or treatment that weakens your immune system, or you currently have an active infection
For one part of the study (Study 1): If not enough bone marrow fluid (at least 10 mL) can be collected after two attempts, you may not be able to continue (confirm with trial site)
For another part of the study (Study 2): If not enough fat tissue (at least 40 mL) can be collected after two attempts, you may not be able to continue (confirm with trial site)
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Sowmya Viswanathan, PhD, University Health Network, Toronto
Phone: 416-634-7240
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Pain Level Changes. Differences in response rates between groups (treatments vs placebos) at 6-months (end of study) compared to baseline. Response is based on an improvement of 2 units or more in the Numeric Pain Rating Scale (NPRS).
Can't join this trial?
Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.