Phase 1 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be 18 years of age or older (there is no upper age limit)
• You must be well enough to carry out basic daily activities — you may need some help but should not be completely unable to care for yourself (confirm with trial site)
• You must have been diagnosed with B-cell acute lymphoblastic leukemia (a type of blood cancer) and be in your first complete remission, meaning your cancer has responded to initial treatment
• Traces of cancer cells must still be detectable in your blood using sensitive tests, even though you are in remission — specific testing methods and timing depend on your cancer type (confirm with trial site)
• You must have enough of a certain type of immune cell (CD3 T cells) in your blood within 21 days before a cell collection procedure
• Any side effects from previous treatments must have mostly settled down to a mild or manageable level
• Your bone marrow must be producing enough blood cells — specifically, your white blood cell and platelet counts must meet minimum levels
• Your kidneys must be working well enough, based on blood tests
• Your liver must be working well enough, based on blood tests
• Your bilirubin (a substance processed by the liver) must be at an acceptable level — a slightly higher level may be allowed if you have a condition called Gilbert's syndrome
• Your heart must be pumping blood effectively, with no significant fluid around the heart and no major abnormalities on a heart tracing test
• Your lungs must be working well enough, with no significant fluid around the lungs, oxygen levels above 92% while breathing normal air, and lung function tests showing at least 50% of expected capacity
• If you are a woman who could become pregnant, you must have a negative pregnancy test before joining
• If you could become pregnant or father a child, you must be willing to use reliable birth control during the study and for 12 months after receiving the treatment
• You must be able to understand and sign a consent form agreeing to take part
• You must be willing to take part in a long-term follow-up study

Who may not be able to join:

• You have previously received a type of treatment called CAR T cell therapy
• Your leukemia has come back or has not responded to treatment, including if you were previously free of detectable cancer cells but cancer traces have returned
• You have a mixed type of leukemia or a specific type called Burkitt's lymphoma
• Your leukemia is not in remission at the time of joining (remission means less than 5% cancer cells in the bone marrow)
• You currently have signs of leukemia affecting your brain or spinal cord, or imaging scans show cancer there — however, if this was treated in the past and there is no current evidence, you may still be eligible
• You have had another cancer in the past, unless you have been cancer-free for at least 3 years — certain skin cancers and very early-stage cancers in specific locations may be exceptions
• You have an active, uncontrolled infection that requires treatment with antibiotics or antifungal/antiviral medicines — minor infections that are responding to treatment may be acceptable
• You have a known history of HIV, hepatitis B, or hepatitis C infection
• You have had a heart attack, heart procedure, unstable chest pain, or other significant heart condition within the past 12 months, or leukemia has spread to your heart
• You have a blood clot (in a vein) that is not being managed with a stable treatment
• You have any other medical condition that the study doctors feel could interfere with the safety or results of the trial
• You have had a severe allergic reaction to any medicines used in this study
• You are a woman planning to become pregnant during the study

Important: Always verify eligibility with the trial site directly before applying.