Phase 3 Myeloma Trial, Recruiting NCT05552222 Sponsor: Janssen Research & Development, LLC Condition: Myeloma
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Phase 3 Myeloma Trial, Recruiting

NCT05552222
Recruiting Phase 3 🇦🇺 Australian site

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who have been diagnosed with multiple myeloma according to standard international diagnostic guidelines
  • People who have been newly diagnosed and are not suitable for high-dose chemotherapy with a stem cell transplant — either because of older age, because other health conditions make that treatment too risky, or because the transplant is being delayed as a first treatment option
  • People whose general physical functioning is rated at a certain level (scored 0 to 2 on a standard scale used by doctors to measure how well a person can carry out daily activities)
  • People who agree not to be pregnant, breastfeeding, or planning to become pregnant during the study or within 6 months after their last dose of study treatment
  • People who agree not to plan to father a child during the study or within 100 days after their last dose of study treatment

Who may not be able to join:

  • People who have already received treatment for multiple myeloma or an earlier stage of the condition called smoldering myeloma, except for a small, short course of steroid medication (within specific dose limits set by the trial)
  • People who have had a blood-filtering procedure called plasmapheresis within 28 days before joining the trial
  • People who have had a stroke, a brief stroke-like episode (sometimes called a mini-stroke), or a seizure within the 6 months before joining the trial
  • People with known allergies or sensitivities to certain study drugs (teclistamab or talquetamab) or their ingredients
  • People for whom certain other study medications (daratumumab or lenalidomide) are not recommended according to standard prescribing guidelines
  • People who score 2 or higher on a specific frailty measurement scale used for myeloma patients, unless that score is based only on age (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 28 July 2026
Phase 3: approximately ~65% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Janssen Research & Development, LLC Clinical Trial, Janssen Research & Development, LLC

Phone: 844-434-4210

Australian sites

Royal Prince Alfred Hospital, Camperdown,
Barwon Health - University Hospital Geelong, Geelong,
Liverpool Hospital, Liverpool,
Sir Charles Gairdner Hospital, Nedlands,
Calvary Mater Newcastle Hospital, New South Wales,
Wollongong Hospital, Wollongong,
Princess Alexandra Hospital, Woolloongabba,

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 3
Registry
ClinicalTrials.gov
Start date
25 October 2022
Est. completion
30 April 2031

Where this trial is recruiting

🇦🇺 Australia 🇦🇹 Austria 🇧🇪 Belgium 🇧🇷 Brazil 🇨🇦 Canada 🇨🇳 China 🇨🇿 Czechia 🇩🇰 Denmark 🇫🇷 France 🇩🇪 Germany 🇬🇷 Greece 🇮🇱 Israel 🇮🇹 Italy 🇯🇵 Japan 🇳🇱 Netherlands 🇳🇴 Norway 🇵🇱 Poland 🇵🇹 Portugal 🇰🇷 South Korea 🇪🇸 Spain 🇸🇪 Sweden 🇨🇭 Switzerland Turkey (Türkiye) 🇬🇧 United Kingdom 🇺🇸 United States

7 site(s) in Australia. Confirm current status and contact details directly with the trial site.

Primary endpoints

Progression Free Survival (PFS); 12-Month Minimal Residual Disease (MRD)-Negative Complete Response (CR)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov