Pulmonary Hypertension Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are between 15 and 80 years old
- You have been diagnosed with pulmonary arterial hypertension (PAH) that has no known cause or runs in your family, confirmed by standard medical tests
- You carry a BMPR2 gene mutation but are otherwise healthy, with normal heart and lung pressure (confirm with trial site)
- You are a healthy person with no heart or lung disease (as a comparison participant)
- Your PAH symptoms fall into a mild to moderate category, meaning you can still do some level of daily activity (WHO functional class I-III)
- Your PAH medications have stayed the same for at least 3 months before joining, with only minor exceptions allowed for water pill (diuretic) adjustments or IV medication side effect management
Who may not be able to join:
- You are unable to move around independently because you use a wheelchair, are bed-bound, rely on a cane or walker, or have another condition that seriously limits your physical activity
- You are currently pregnant
- Your PAH has a known cause other than being inherited or having no identified cause (for example, PAH linked to another disease)
- Your heart failure symptoms are very severe, placing you in the most serious category (functional class IV)
- Your water pill (diuretic) dose has needed to be changed more than twice in the past 3 months
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Evan Brittain, MD, Vanderbilt Medical Center
Phone: (615) 343-4682
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change in Quality of Life as measured by the emPHasis-10; Change in Quality of Life as measured by the Pediatric Quality of Life Inventory Version 4.0; Change in meters walked in six-minute walk distance (meters); Change in diffusing capacity for carbon monoxide (DLCO) on the Pulmonary Function Test; Change in Tricuspid Annular Plane Systolic Excursion (TAPSE), expressed in mm.; Change in Tricuspid Annular Velocity (S'), as assessed by echocardiogram results, expressed in cm/sec; Change in Estimated Right Ventricle (RV) Systolic Pressure, as assessed by echocardiogram results, expressed in mmH...
Can't join this trial?
Data last synced from ClinicalTrials.gov: 14 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.