Phase 2 Alopecia Areata Trial, Completed

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with alopecia areata (AA) as the only known reason for your hair loss
• You have lost at least 35% of your scalp hair, as measured by a standard scoring tool called SALT, at the time of your screening and baseline visits
• Your current episode of hair loss has been going on for more than 6 months but less than 7 years at the time of screening
• There has been no noticeable new hair regrowth in the 6 months before your baseline visit

Who may not be able to join:

• You have, or have had, male or female pattern baldness (the common inherited type of hair loss)
• You have had a hair transplant on your scalp
• You have another scalp condition that could affect how your hair loss is measured or that needs treatment applied to the scalp
• You are unwilling to keep a consistent hairstyle, use the same shampoo and hair products throughout the study, or avoid weaves, extensions, or shaving your scalp
• You plan to use a glued-on or hard-to-remove hairpiece or wig during the study
• You have had a major surgery or serious injury within the past 8 weeks, have surgery coming up soon, or have planned surgery scheduled during the study
• You have taken part in another clinical trial involving an experimental drug within the past 4 weeks before your baseline visit
• You have taken an oral JAK inhibitor medication within the past 6 months before your baseline visit
• You have previously taken an oral JAK inhibitor for alopecia areata for 12 weeks or more without seeing at least a 25% improvement in your hair loss score
• You have received a cell-depleting treatment (such as rituximab) within the past 6 months, or until your immune cell levels return to normal, whichever is longer
• You have received a biologic medication within the past 12 weeks, or within a specific washout period based on the medication, whichever is longer
• You have taken oral immune-suppressing medications within the past 8 weeks before your baseline visit
• You have had steroid injections or platelet-rich plasma (PRP) injections into your scalp within the past 6 weeks
• You have used light therapy, certain skin sensitising or irritating treatments, or cryotherapy (freezing treatment) within the past 4 weeks
• You have used any topical treatments on your scalp, eyebrows, or eyelashes (such as steroid creams, JAK inhibitor creams, medicated shampoos, minoxidil, or herbal hair products that could affect hair loss) within the past 4 weeks
• You have a significant, ongoing, or poorly controlled condition affecting your kidneys, liver, blood, digestive system, hormones, lungs, heart, mental health, immune system, or nervous system
• You have a known condition that weakens your immune system
• You have had a solid organ or bone marrow/blood cell transplant
• You have a history of lymphoma or other cancer, except for certain treated skin cancers or cervical cancer with no signs of return
• You currently have, or recently had, a significant infection (either short-term or ongoing)
• Certain blood test results at screening are outside acceptable ranges, including low levels of a type of white blood cell, raised liver enzyme levels, raised bilirubin levels, or raised creatinine (kidney function) levels (confirm exact thresholds with trial site)

Important: Always verify eligibility with the trial site directly before applying.