Phase 2 Breast Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Women aged 18 or older
• People with a confirmed diagnosis of invasive breast cancer that is hormone receptor positive (HR+) and HER2 negative, based on tissue testing
• People whose breast cancer is locally advanced and cannot be fully treated with surgery or radiation, or whose cancer has come back or spread to other parts of the body
• People with HR+/HER2- advanced breast cancer who have previously been treated with a type of drug called a CDK4/6 inhibitor
• People who have at least one tumour that can be measured on a scan, and that has not previously been treated with radiotherapy
• People whose blood counts and organ function (including liver and kidneys) meet certain minimum levels set by the trial (confirm with trial site for exact values)
• People who have not received radiotherapy, targeted therapy, or surgery in the 3 weeks before starting the trial, and whose side effects from previous treatments have settled — with no or only very mild nerve-related side effects
• People with a general health score (called an ECOG score) of 2 or lower, and a life expectancy of at least 3 months
• People who are capable of becoming pregnant and agree to use a medically approved method of contraception during the trial and for at least 3 months after the last dose of the study drug
• People who agree to participate voluntarily, sign a consent form, and commit to attending follow-up appointments

Who may not be able to join:

• People who have received chemotherapy, radiotherapy (other than for pain relief), or immunotherapy in the 3 weeks before starting the trial (bone-strengthening drugs called bisphosphonates are allowed)
• People with brain or central nervous system metastases that are not well controlled, or that require ongoing medication such as steroids to manage symptoms
• People who have had a significant heart condition in the past 6 months, such as heart failure, chest pain (angina), heart attack, or serious irregular heart rhythms
• People who still have ongoing side effects rated grade 1 or higher from previous cancer treatments (with some exceptions, such as hair loss, that researchers may decide do not apply — confirm with trial site)
• People who have had major surgery within 3 weeks before the trial starts (minor procedures such as fitting a port or line are generally not included in this)
• People who are currently pregnant or breastfeeding
• People who have had another type of cancer in the past 5 years, other than fully cured skin basal cell carcinoma or cervical carcinoma in situ

Important: Always verify eligibility with the trial site directly before applying.